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Published (Version of record)CC BY-NC V4.0, Open Access
Published (Version of record)CC BY-NC V4.0, Open
Journal article
Is 6-Shogaol an Effective Phytochemical for Patients With Lower-risk Myelodysplastic Syndrome? A Narrative Review
Integrative Cancer Therapies, Vol.20, pp.1-12
01/01/2021
PMCID: PMC8728773
PMID: 34930049
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Source: InCites
Abstract
Myelodysplastic syndrome (MDS) evolves due to genomic instability, dysregulated signaling pathways, and overproduction of inflammatory markers. Reactive oxygen species contribute to the inflammatory response, which causes gene damage, cellular remodeling, and fibrosis. MDS can be a debilitating condition, and management options in patients with MDS aim to improve cytopenias, delay disease progression, and enhance quality of life. High serum ferritin levels, a source of iron for reactive oxygen species production, correlate with a higher risk of progression to acute myeloid leukemia, and iron overload is compounded by blood transfusions given to improve anemia. 6-shogaol is a natural phenolic compound formed when ginger is exposed to heat and/or acidic conditions, and it has been shown to possess anti-tumor activity against leukemia cell lines and antioxidant effects. This narrative review assessed the potential benefits of this phytochemical in lower-risk MDS patients through examining the current evidence on the pharmacological and therapeutic properties of ginger and 6-shogaol.
Details
- Title
- Is 6-Shogaol an Effective Phytochemical for Patients With Lower-risk Myelodysplastic Syndrome? A Narrative Review
- Creators
- Soo Liang Ooi - Charles Sturt UniversityRon Campbell - Charles Sturt UniversitySok Cheon Pak - Charles Sturt UniversityTerry Golombick - St George HospitalArumugam Manoharan - Southern Sydney Haematology, Kogarah, NSW, Australia, University of Wollongong Australia, Wollongong NSW, AustraliaRaj Ramakrishna - Southern Sydney Haematology, Kogarah, NSW, Australia, University of Wollongong Australia, Wollongong NSW, AustraliaVladimir Badmaev - American Medical Holdings, Inc., Staten Island, NY, USAJanet Schloss - Southern Cross University
- Publication Details
- Integrative Cancer Therapies, Vol.20, pp.1-12
- Publisher
- Sage Publications, Inc
- Identifiers
- 991012987891202368
- Copyright
- © The Author(s) 2021 Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons AttributionNonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
- Academic Unit
- Faculty of Science and Engineering; Science; National Centre for Naturopathic Medicine
- Language
- English
- Resource Type
- Journal article