Journal article
Xueshuantong Injection (Lyophilized) Attenuates Cerebral Ischemia/Reperfusion Injury by the Activation of Nrf2-VEGF Pathway
Neurochemical Research, Vol.43, pp.1096-1103
2018
PMID: 29633164
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Source: InCites
Abstract
Xueshuantong injection (Lyophilized, XST), extracted from the traditional Chinese medicinal herb Panax notoginseng, has neuroprotective effect on cerebral ischemia. Revascularization of ischemic tissue is good for the therapy of cerebrovascular disease. In this study, angiogenic potentiality and possible mechanism of XST for cerebral ischemia were explored. Rats were subjected to transient middle cerebral artery occlusion (MCAO), and then intraperitoneally administered with XST daily for 3 or 7 consecutive days. The neurological function deficits, and endogenous antioxidant capacity were evaluated. Post-stroke angiogenesis and vascularization were assessed by ELISA and immunohistochemical staining. Transcription levels of Nrf2, HO-1, NQO1 in brain tissues were analyzed by real-time RT-PCR. The results showed that XST could remarkably ameliorate neuronal functional deficit, promote angiogenesis and vascularization after MCAO. The mechanism of angiogenesis might be related to endogenous antioxidant capacity and Nrf2 pathway. In conclusion, administered XST for 7 days after stroke could significantly improve functional recovery and promote angiogenesis, that might be related to Nrf2 signaling pathway. These findings could provide scientific evidence for the use of XST in cerebral ischemic diseases and provide theoretical support for further studies.
Details
- Title
- Xueshuantong Injection (Lyophilized) Attenuates Cerebral Ischemia/Reperfusion Injury by the Activation of Nrf2-VEGF Pathway
- Creators
- Hong Guo (Author) - Tianjin University of Traditional Chinese MedicineDickson Adah (Author) - Tianjin University of Traditional Chinese MedicinePeter Bai James (Author) - Tianjin University of Traditional Chinese MedicineQingqing Liu (Author) - Tianjin University of Traditional Chinese MedicineGuozheng Li (Author) - Tianjin University of Traditional Chinese MedicinePeter Ahmadu (Author) - Tianjin University of Traditional Chinese MedicineLijuan Chai (Author) - Tianjin University of Traditional Chinese MedicineShaoxia Wang (Author) - Tianjin University of Traditional Chinese MedicineYang Liu (Author) - Tianjin University of Traditional Chinese MedicineLimin Hu (Author) - Tianjin University of Traditional Chinese Medicine
- Publication Details
- Neurochemical Research, Vol.43, pp.1096-1103
- Publisher
- United States
- Identifiers
- 991012921899302368
- Academic Unit
- National Centre for Naturopathic Medicine; Faculty of Health
- Language
- English
- Resource Type
- Journal article