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Published (Version of record)CC BY V4.0, Open Access
Published (Version of record)CC BY V4.0, Open
Journal article
Twelve Weeks of Oral L-Serine Supplementation Improves Glucose Tolerance, Reduces Visceral Fat Pads, and Reverses the mRNA Overexpression of Renal Injury Markers KIM-1, IL-6, and TNF-α in a Mouse Model of Obesity
Nutraceuticals, Vol.3(2), pp.262-273
24/05/2023
Appears in Recent Faculty of Health Publications
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Abstract
Comorbidities associated with obesity, including diabetes and kidney diseases, greatly increase mortality rates and healthcare costs in obese patients. Studies in animal models and clinical trials have demonstrated that L-serine supplementation is a safe and effective therapeutic approach that ameliorates the consequences of obesity. However, little is known about the effects of L-Serine supplementation following high-fat diet (HFD) consumption and its role in the mRNA expression of markers of kidney injury. We provide a descriptive action by which L-serine administration ameliorated the consequences of HFD consumption in relation to weight loss, glucose homeostasis as well as renal mRNA expression of markers of kidney injury. Our results indicated that L-Serine supplementation in drinking water (1%, ad libitum for 12 weeks) in male C57BL/6J mice promoted a significant reduction in body weight, visceral adipose mass (epididymal and retroperitoneal fat pads) as well as blood glucose levels in mice consuming a HFD. In addition, the amino acid significantly reduced the mRNA expression of the Kidney Injury Marker 1 (KIM-1), P2Y purinoceptor 1 (P2RY1), as well as pro-inflammatory cytokines (IL-6 and TNFα). L-serine administration had no effect on mice consuming a standard chow diet. Collectively, our findings suggest that L-serine is an effective compound for long-term use in animal models and that it ameliorates the metabolic consequences of HFD consumption and reduces the elevated levels of renal pro-inflammatory cytokines occurring in obesity.
Details
- Title
- Twelve Weeks of Oral L-Serine Supplementation Improves Glucose Tolerance, Reduces Visceral Fat Pads, and Reverses the mRNA Overexpression of Renal Injury Markers KIM-1, IL-6, and TNF-α in a Mouse Model of Obesity
- Creators
- Duyen TranMuhammad Ishaq - University of TasmaniaCheng Yang - University of TasmaniaTauseef Ahmad - University of Tasmania (Australia, Launceston)Maurizio RonciMariachiara Zuccarini - University of Chieti-PescaraStephen Myers - University of Tasmania (Australia, Launceston)Courtney McGowan - University of Tasmania (Australia, Launceston)Rajaraman Eri - University of Tasmania (Australia, Launceston)Darren C. Henstridge - University of Tasmania (Australia, Launceston)Sabrina Sonda - University of TasmaniaCourtney McGowan - University of TasmaniaVanni Caruso
- Publication Details
- Nutraceuticals, Vol.3(2), pp.262-273
- Publisher
- MDPI
- Number of pages
- 12
- Identifiers
- 991013241861502368
- Copyright
- © 2023 by the authors
- Academic Unit
- Faculty of Health; Human Sciences
- Language
- English
- Resource Type
- Journal article