Trimethoprim-sulfonamide (TMPS) combinations are widely used to treat a range of infectious diseases in horses, but some equine practitioners are reluctant to use them for treatment of both neonatal and older foals. Considering the emergence of increased antimicrobial resistance, the use of protected antimicrobials commonly prescribed to foals should be avoided and alternative first-line therapy considered, where appropriate. This review examines the characteristics and pharmacokinetics of TMPS and its suitability for treatment of foals. Data regarding dosage and route of administration are reported on the basis of recent publications in foals. The review intends to share significant information about the common infections that are most likely responsive to TMPS treatment in foals and, as such, where TMPS might be considered a suitable first-line therapeutic option.
Details
Title
Trimethoprim-sulfonamide: a valid antimicrobial treatment in foals?
Creators
Kajsa Gustafsson - University of Milan
Benjamin W Sykes - Southern Cross University
Denis Verwilghen - The University of Sydney
Katrien Palmers - Equine Clinic De Morette (Asse, Belgium)
Stacey Sullivan - Goulburn Valley Equine Hospital
Gaby van Galen - The University of Sydney
Publication Details
Journal of the American Veterinary Medical Association, Vol.262(6)
Publisher
American Veterinary Medical Association; SCHAUMBURG