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Treatment of signs and symptoms of the common cold using EPs 7630 - results of a meta-analysis523.27 kB
Published (Version of record)CC BY V4.0, Open Access
Published (Version of record)CC BY V4.0, Open
Journal article
Treatment of signs and symptoms of the common cold using EPs 7630 - results of a meta-analysis
Heliyon, Vol.5(11), E02904
11/2019
PMCID: PMC6888731
PMID: 31844762
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Source: InCites
Abstract
The efficacy of Pelargonium sidoides preparation EPs 7630 in the common cold (CC) was assessed by performing meta-analyses of randomized, double-blind, placebo-controlled trials. Mean differences (MD) and risk ratios (RR) with their 95% confidence intervals (CI) were computed. Five trials with a total of 833 patients were included. All trials had a treatment period of ten days with visits at days 3, 5, and 10 after baseline and used a ten-symptom Cold Intensity Score (CIS) as the primary outcome. Significant differences favoring EPs 7630 were observed for total CIS reduction (day 5: MD = -2·30; 95%CI = -4·12,-0·49; day 10: MD = -1·16; 95%CI = -2·22,-0·10), proportion of patients with substantial improvement (day 5: RR = 1·73; day 10: RR = 1·06) and complete remission (day 5: RR = 2·52; day 10: RR = 2·13). Subjects treated with EPs 7630 missed fewer days at work, used less paracetamol and had an improved sleep quality. No serious adverse reactions to EPs 7630 were reported. The results support the efficacy of EPs 7630 in adults with CC.
Details
- Title
- Treatment of signs and symptoms of the common cold using EPs 7630 - results of a meta-analysis
- Creators
- Andreas Schapowal - Allergy Clinic, Hochwangstraβe 3, 7302 Landquart, Switzerland.Gustav Dobos - University of Duisburg-EssenHolger Cramer - University of Duisburg-EssenKian Chung Ong - KC Ong Chest & Medical Clinic, 3 Mount Elizabeth #12-03, Mount Elizabeth Medical Centre, Singapore 228510.Martin Adler - University of MünsterAndrea Zimmermann - Dr Willmar SchwabeJuliette Brandes-Schramm - Dr Willmar SchwabeWalter Lehmacher - University of Cologne
- Publication Details
- Heliyon, Vol.5(11), E02904
- Publisher
- Elsevier Ltd
- Identifiers
- 991013036333702368
- Copyright
- © 2019 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Academic Unit
- National Centre for Naturopathic Medicine
- Language
- English
- Resource Type
- Journal article