Journal article
Training by low-frequency stimulation of tibialis anterior in spinal cord-injured men
Muscle & Nerve, Vol.25(5), pp.685-694
2002
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Source: InCites
Abstract
<p>The tibialis anterior muscle of nine paraplegic men was chronically stimulated (2-6 h per day; at 10 Hz, 5 s on, 5 s off) under isometric loading conditions for 5 days per week for 4 weeks. After 4 weeks of training, muscle fatigue resistance in an electrically evoked test had increased by an average of 75% (P < .01, n = 9), but there were no changes in the relative composition of the three myosin heavy chain (MHC) isoforms. Five of the subjects continued training for an additional 5 weeks (2 h per day, 3 days per week). Although there was a tendency for twitch time to peak torque to increase after this additional period, no change occurred in relative MHC isoform content. However, in situ hybridization analysis revealed that even after 2 weeks of stimulation, there was evidence of upregulation of the mRNA for the MHC-I isoform and downregulation of the MHC-IIX isoform, a development that continued in weeks 4 and 9. This study provides evidence, at the level of gene transcription, that a fast-to-slow change in MHC isoform composition may be possible in human muscle when its usage is significantly increased.</p>
Details
- Title
- Training by low-frequency stimulation of tibialis anterior in spinal cord-injured men
- Creators
- Stephen DR Harridge - Copenhagen Muscle Research CentreJesper L Andersen - Copenhagen Muscle Research CentreAndreas Hartkopp - Copenhagen Muscle Research CentreShi Zhou - Southern Cross UniversityFin Biering-Sorensen - Copenhagen Muscle Research CentreClaudia Sandri - Centre of Muscle Biology and Physiopathology, PadovaMichael Kjaer - Copenhagen Muscle Research Centre
- Publication Details
- Muscle & Nerve, Vol.25(5), pp.685-694
- Identifiers
- 1429; 991012821817602368
- Academic Unit
- Faculty of Health; Human Sciences; School of Health and Human Sciences
- Resource Type
- Journal article