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Published (Version of record)CC BY V4.0, Open Access
Published (Version of record)CC BY V4.0, Open
Journal article
The influence of environmental exposures during the preconception period on offspring outcomes: a systematic review
Frontiers in public health, Vol.13, pp.1-45
17/12/2025
Appears in Recent Faculty of Health Publications
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Abstract
Introduction: Health behaviors and exposures to environmental hazards among individuals of reproductive age prior to pregnancy can influence maternal and child health outcomes. While research attention has focused on preconception health behaviors, such as diet and lifestyle, there is emerging evidence that environmental exposures may also be important to consider.
Methods: A search strategy (PROSPERO # CRD42021240069) was developed for MEDLINE (OVID), EMBASE (OVID), Maternity and Infant Care (OVID), CINAHL (EBSCO), and PsycINFO (EBSCO). Searches were conducted from database inception until 21 May 2021. Studies were included that investigated male or female exposure to any environmental hazard during the preconception period and reported neonatal or child health outcomes. No limit to date of publication, language or comparator were applied. Studies were critically appraised using the Newcastle-Ottawa Quality Assessment Scale for Cohort studies.
Results: The review identified 63 studies that met the inclusion criteria, published between 1974 and 2021. They encompassed studies that covered ambient exposures (n = 23), chemical exposures (n = 26), and other exposures (n = 24). For ambient exposures, all studies examined the outcomes associated with air pollution and one study also explored associations with exposure to hot and cold ambient temperature. Studies investigating chemical exposures encompassed endocrine-disrupting chemicals (n = 4), pesticides (n = 10), persistent organic pollutants (n = 4), and organic solvents (n = 7). Other exposures studied were categorized as radiation (n = 9), metals (n = 4) and undifferentiated products or compounds (n = 14). Outcomes measured by the included studies covered congenital malformations, adverse birth outcomes and childhood illness. There was a high level of heterogeneity across the included studies that precluded meta-analysis. Various associations between exposures and outcomes were identified.
Discussion: There is growing evidence of adverse outcomes in offspring associated with maternal and paternal environmental exposures during the pre-conception period. While there are some topics that have received focused attention from research teams in the last 50 years, most studies appear to be standalone and have not continued to develop as part of wider research programs. There is need to develop a field-wide approach to create an agenda for environmental preconception health exposures and outcomes that supports more coordinated, targeted and strategic research efforts.
Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42021240069
Details
- Title
- The influence of environmental exposures during the preconception period on offspring outcomes: a systematic review
- Creators
- Amie Steel - University of Technology SydneyWen Ray Lee - The University of QueenslandZhiwei Xu - Griffith University (Australia, Gold Coast)Jenny Carè - University of Technology SydneyJavier Cortes-Ramirez - Queensland University of TechnologyCarrie Thomson-Casey - University of Technology SydneyDwan Vilcins - The University of Queensland
- Publication Details
- Frontiers in public health, Vol.13, pp.1-45
- Publisher
- Frontiers Media S.A.; LAUSANNE
- Grant note
- Amie SteelARC Future Fellowship: FT220100610
The author(s) declare that financial support was received for the research and/or publication of this article. Amie Steel was funded through an ARC Future Fellowship (FT220100610).
- Identifiers
- 991013337876602368
- Copyright
- © 2025 Steel, Lee, Xu, Carè, Cortes-Ramirez, Thomson-Casey and Vilcins.
- Academic Unit
- Human Sciences; National Centre for Naturopathic Medicine; Faculty of Health
- Language
- English
- Resource Type
- Journal article