Journal article
The impact of moderate distance recreational running and ageing on cardiac physiology
Heart (British Cardiac Society), Vol.103, pp.219-226
13/01/2017
PMID: 27530134
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Source: InCites
Abstract
Objective Exercise-induced cardiac dysfunction and corollary biomarker release have been documented following long-distance running events. To what degree these processes occur during shorter distance running events is unknown.
Methods 72 healthy recreational runners (54% male/46% female) recruited by age (group 1 (18–20 years old, N=19); group 2 (45–50 years old, N=27); group 3 (70–75 years old, N=26)) were studied with echocardiography and biochemical profiling during participation in a 10 km running race.
Results Despite age-dependent baseline differences in ventricular size and diastolic tissue velocities, there were no significant within group or across group decrements in ventricular systolic or diastolic function following race completion. Postrace increases in cardiac troponin-I (cTnI), B-type natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hs-CRP) were common and demonstrated distinct age dependent profiles. Specifically, BNP increases were most pronounced among older runners (group 3Δ: 16±22 pg/mL, p=0.001), hs-CRP increased only among younger runners (group 1Δ: 1.5±2.7 mg/L, p=0.03) and cTnI increased in both younger (group 1Δ: 0.01±0.02 ng/mL, p=0.028) and older (group 3Δ: 0.01±0.01 ng/mL, p=0.007) runners, but not middle aged runners (group 2Δ: 0.00±0.00 ng/mL, p=0.57).
Conclusions Moderate distance recreational running leads to distinct age-dependent biomarker release but is not associated with cardiac fatigue, a proposed stimulus for pathologic cardiac remodelling that has been observed following longer distance running events.
Details
- Title
- The impact of moderate distance recreational running and ageing on cardiac physiology
- Creators
- Jonathan H Kim - Emory Clinical Cardiovascular Research Institute (Atlanta, Georgia, USA)Yi-An Ko - Emory UniversityJeff Hedley - Emory Clinical Cardiovascular Research Institute (Atlanta, Georgia, USA)James MacNamara - Emory Clinical Cardiovascular Research Institute (Atlanta, Georgia, USA)Mosaab Awad - Emory Clinical Cardiovascular Research Institute (Atlanta, Georgia, USA)William Taylor - Emory Clinical Cardiovascular Research Institute (Atlanta, Georgia, USA)Sean Healy - Emory Clinical Cardiovascular Research Institute (Atlanta, Georgia, USA)Hiroshi Aida - Emory Clinical Cardiovascular Research Institute (Atlanta, Georgia, USA)Ngoc-Anh Le - Veterans’ Affairs Medical Center (Atlanta, Georgia, USA)Peter W Wilson - Emory Clinical Cardiovascular Research Institute (Atlanta, Georgia, USA)Melissa White - Emory UniversityLaurence S Sperling - Emory Clinical Cardiovascular Research Institute (Atlanta, Georgia, USA)Joseph S Wilson - Atlanta Track Club, Atlanta, Georgia, USAAaron L Baggish - Massachusetts General Hospital
- Publication Details
- Heart (British Cardiac Society), Vol.103, pp.219-226
- Publisher
- BMJ Group
- Identifiers
- 991013099200902368
- Copyright
- (c) Published by the BMJ Publishing Group Limited.
- Academic Unit
- School of Environment, Science and Engineering
- Language
- English
- Resource Type
- Journal article