Journal article
The effects of physical exercise in the palliative care phase for people with advanced cancer: a systematic review with meta-analysis
Journal of cancer survivorship, Vol.17, pp.399-415
04/2023
PMID: 35040076
Appears in Recent Faculty of Health Publications
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Source: InCites
Abstract
Purpose
The purpose of this systematic review with meta-analysis was to evaluate the safety, feasibility and effectiveness of exercise in the palliative care phase for people with advanced cancer.
Methods
Electronic databases were searched for exercise randomised controlled trials involving individuals with incurable cancer that were published prior to April 14, 2021. Meta-analyses were performed to evaluate the effects of exercise on health outcomes. Subgroup effects for exercise mode, supervision, intervention duration and cancer diagnosis were assessed.
Results
Twenty-two trials involving interventions ranging between 2 weeks and 6 months were included. Interventions comprised of aerobic (n = 3), resistance (n = 4), mixed-mode (n = 14) and other exercise (n = 1) modalities. Cancer types consisted of lung (n = 6), breast (n = 3), prostate (n = 2), multiple myeloma (n = 1) and mixed cancer types (n = 10). Meta-analysis of 20 RCTs involving 1840 participants showed no difference in the risk of a grade 2–4 adverse event between exercise and usual care (n = 110 adverse events (exercise: n = 66 events; usual care: n = 44 events), RD = − 0.01 (91% CI = − 0.01, 0.02); p = 0.24). Overall median recruitment, retention and adherence rates were 56%, 80% and 69%, respectively. Meta-analysis of health outcomes showed effects in favour of exercise for quality of life, fatigue, aerobic fitness and lower-body strength (SMD range = 0.27–0.48, all p < 0.05).
Conclusions
Participants who engaged in exercise experienced an increase in quality of life, fitness and strength and a decrease in fatigue.
Implications for Cancer Survivors
Physical activity programs were found to be safe and feasible for people with advanced cancer in the palliative care phase.
Details
- Title
- The effects of physical exercise in the palliative care phase for people with advanced cancer: a systematic review with meta-analysis
- Creators
- Kellie Toohey - University of CanberraMichael Chapman - Australian National UniversityAnne-Marie Rushby - Australian Institute of Health and WelfareKat Urban - Lismore Base HospitalGemma Ingham - Prince of Wales HospitalBenjamin Singh - Greenslopes Private Hospital
- Publication Details
- Journal of cancer survivorship, Vol.17, pp.399-415
- Publisher
- Springer Nature
- Number of pages
- 17
- Identifiers
- 991013139812602368
- Copyright
- © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.
- Academic Unit
- Faculty of Health
- Language
- English
- Resource Type
- Journal article