Journal article
The effects of multimodal exercise on cognitive and physical functioning and brain-derived neurotrophic factor in older women: a randomised controlled trial
Age and Ageing, Vol.43(5), pp.623-629
09/2014
PMID: 24554791
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Abstract
Objective: to test the effect of a 16-week multimodal exercise program on neurocognitive and physical functioning and brainderived neurotrophic factor (BDNF).
Design: a single-blinded, parallel-group randomised controlled trial.
Settings: university campus and community-based halls.
Subjects: forty-nine women aged 65 to 75 years, with no cognitive impairment and not undertaking more than 1 h of formal
exercise training per week.
Methods: the intervention group attended a 60-min multimodal class twice each week which included cardiovascular, strength
and motor fitness training. The primary outcome was neurocognitive functioning and secondary outcomes were physical functioning and plasma levels of BDNF.
Results: twenty-five participants were randomised to the intervention group and 24 to the control group. One control participant withdrew before follow-up data collection. The intervention group performed significantly better than the control group
at follow-up (when controlled for baseline) in the Trail Making test A and B, the California Older Adult Stroop test (Word,
Interference and Total scores), Controlled Oral Word Association test and the Timed Up-and-Go test, Six-Minute Walk test,
One-Legged Stance test and plasma BDNF.
Conclusion: this multimodal exercise program resulted in neurocognitive and physical performance improvements and
increased levels of plasma BDNF, in older women, when compared with controls. This RCT provides evidence that a multimodal exercise intervention can achieve larger effect sizes than those generally resulting from single modality interventions.
Increases in BDNF levels imply neurogenesis may be a component of the mechanism underpinning the cognitive improvements associated with multimodal exercise.
Details
- Title
- The effects of multimodal exercise on cognitive and physical functioning and brain-derived neurotrophic factor in older women: a randomised controlled trial
- Creators
- Sue Vaughan - Griffith University, School of Rehabilitation Sciences, G02 Gold Coast Campus, Gold Coast, QLD 4222, AustraliaMarianne Wallis - University of the Sunshine Coast, School of Nursing and Midwifery, Sunshine Coast, QLD, Australia Griffith University, Research Centre for Health Practice Innovation, Gold Coast, QLD, AustraliaDenise Polit - Griffith University, Research Centre for Health Practice Innovation, Gold Coast, QLD, AustraliaMike Steele - Griffith University, Graduate Research School, Gold Coast, QLD, Australia Mathematical and Computing Sciences, Faculty of Science, Universiti Brunei Darussalam, Darussalam, BruneiDavid Shum - Griffith University, Griffith Health Institute, Gold Coast, QLD, AustraliaNorman Morris - Griffith University, School of Rehabilitation Sciences, G02 Gold Coast Campus, Gold Coast, QLD 4222, Australia
- Publication Details
- Age and Ageing, Vol.43(5), pp.623-629
- Publisher
- Oxford University Press; England
- Identifiers
- 991012926997802368
- Academic Unit
- Faculty of Health; Nursing
- Language
- English
- Resource Type
- Journal article