Journal article
The effects of moderate intensity training in a hypoxic environment on transcriptional responses in thoroughbred horses
Biology Open, Vol.6, pp.1035-1040
2017
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Source: InCites
Abstract
<p>This study investigated the effects of six weeks of normobaric hypoxic training on transcriptional expression of the genes associated with mitochondrial and glycolytic activities in Thoroughbred horses. Eight horses were divided into two groups of four. They completed an identical incremental, moderate intensity training program, except that one group trained in a hypoxic chamber with 15% oxygen for 30 minutes on alternate days except Sundays (HT), while the other group trained in normal air (NC). Prior to and post the training, heart rate and blood lactate were measured during an incremental treadmill test. Muscle biopsy samples were taken prior to and 24 hours post the training period for qPCR analysis of mRNA changes in VEGF, PPARγ, HIF-1α, PGC-1α, COX4, AK3, LDH, PFK, PKm and SOD-2. No significant differences between the HT and NC were detected by independent-samples t-test with Bonferroni correction for multiple comparisons (<em>P</em>>0.05) in relative changes of mRNA abundance. There were no significant differences between groups for heart rate and blood lactate during the treadmill test. The outcomes indicated that this hypoxia training program did not cause a significant variation in basal level expression of the selected mRNAs in Thoroughbreds as compared with normoxic training.</p>
Details
- Title
- The effects of moderate intensity training in a hypoxic environment on transcriptional responses in thoroughbred horses
- Creators
- Allan Davie - Southern Cross UniversityLi Wen - Tianjin University of SportsAndrew RE Cust - Ballarat Veterinary PracticeRosalind Beavers - Southern Cross UniversityTom Fyfe - Pulford Air and Gas SydneyShi Zhou - Southern Cross University
- Publication Details
- Biology Open, Vol.6, pp.1035-1040
- Identifiers
- 3402; 991012820858502368
- Academic Unit
- Human Sciences; School of Health and Human Sciences; Faculty of Health
- Resource Type
- Journal article