Journal article
The effect of chronic lithium treatment on hippocampal progenitor cells: Transcriptomic analysis and systems pharmacology
Brain and behavior, Vol.13(10), pp.1-11
01/10/2023
PMID: 37553827
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Abstract
Objective: To identify the genomics underpinning the increased volume of the hip-pocampus after long-term administration of lithium (Li) in bipolar disorder patients,hypothesizing the possible contribution of cell growth and differentiation pathways tothis complication.
Methods: RNA-seq profiles of four samples of hippocampal progenitor cells chron-ically treated with a high dose of Li and three samples chronically treated with thetherapeutic dose were retrieved from NCBI-GEO. The raw data underwent filtration,quality control, expression fold change, adjusted significance, functional enrichment,and pharmacogenomic analyses.
Results: CCND1, LOXL2, and PRNP were identified as the genes involved in the drugresponse and the chronic effects of Li in the hippocampal cells. GSK-3β was also ahub in the pharmacogenomic network of Li. In addition, ZMPSTE24 and DHX35 wereidentified as the important genes in lithium therapy.
Conclusions: As shown by gene ontology results, these findings conclude that lithiummay increase the size of the hippocampus in bipolar patients by stimulating the gener-ation of new neurons and promoting their differentiation into neuroblasts, neurons, ormicroglia.
Details
- Title
- The effect of chronic lithium treatment on hippocampal progenitor cells: Transcriptomic analysis and systems pharmacology
- Creators
- Mina Jahandideh - Kermanshah University of Medical SciencesErfan Ebrahimi - Kermanshah University of Medical SciencesMohammad Hosein Farzaei - Kermanshah University of Medical SciencesEbrahim Barzegari - Kermanshah University of Medical Sciences
- Publication Details
- Brain and behavior, Vol.13(10), pp.1-11
- Publisher
- John Wiley and Sons Inc
- Grant note
- This work was supported by the Deputy of Research and Tech. ofKermanshah University of Medical Sciences [grant number: 980791].
- Identifiers
- 991013400558302368
- Copyright
- © 2023 The Authors.
- Academic Unit
- Faculty of Health
- Language
- English
- Resource Type
- Journal article