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Journal article
The effect of MEditerranean DIet and MINdfulness eating on Depression severity in people with major depressive disorder and obesity (MEDIMIND) - a study protocol of a randomized controlled clinical trial with multifactorial design
British journal of nutrition, Vol.First online
17/12/2025
PMID: 41403078
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Abstract
Obesity and depression are highly prevalent diseases that are strongly correlated. At the same time, there is a growing gap in care, and treatment options should be improved and extended. Positive effects of a mediterranean diet on mental health have already been shown in various studies. Additionally to physiological effects of nutrients, the way how food is eaten, such as mindful eating, seems to play a role. The present study investigates the effect of a mediterranean diet and mindful eating on depression severity in people with clinically diagnosed major depressive disorder and obesity. Participants will be randomized to one of the four intervention groups (mediterranean diet, mindful eating, their combination and a befriending control group). The factorial design allows investigating individual effects as well as potential synergistic effects of the interventions. The study consists of a 12-week intervention period, where five individual appointments will take place, followed by a 12-week follow up. The primary outcome is depression severity. Secondary outcomes are remission of depression, assessor-rated depression severity, quality of life, self-efficacy, BMI, waist-to-hip ratio and body composition, also adherence to mediterranean diet and mindful eating will be assessed. Alongside, mediator and moderator analysis, a microbiome analysis, a qualitative evaluation and an economic analysis will be conducted. The study investigates an important health issue in a vulnerable target group. It allows to draw valuable conclusions regarding effectiveness of different interventions, and therefore contributes to improving available care options for people suffering from depression and obesity.
Details
- Title
- The effect of MEditerranean DIet and MINdfulness eating on Depression severity in people with major depressive disorder and obesity (MEDIMIND) - a study protocol of a randomized controlled clinical trial with multifactorial design
- Creators
- Alina Moosburner - University Hospital Tübingen (Tübingen, Germany)Mirela Bilc - University Hospital Tübingen (Tübingen, Germany)Dennis Anheyer - University Hospital Tübingen (Tübingen, Germany)Alina Schleinzer - University Hospital Tübingen (Tübingen, Germany)Samaneh Rahmdel - University of TübingenFrank Vitinius - Robert Bosch HospitalHolger Cramer - University Hospital Tübingen (Tübingen, Germany)
- Publication Details
- British journal of nutrition, Vol.First online
- Publisher
- Cambridge University Press
- Grant note
- The study is partially funded by the Robert Bosch Gesellschaft für Medizinische Forschung mbH (grant number 2024-08).
- Identifiers
- 991013337876802368
- Copyright
- © The Author(s), 2025
- Academic Unit
- National Centre for Naturopathic Medicine
- Language
- English
- Resource Type
- Journal article