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The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: T.C. is funded under a Commonwealth Government research training stipend (RTP stipend). D.S. is supported by the National Institute for Health and Care Research (NIHR) through an NIHR Advanced Fellowship (NIHR302955) and the NIHR Southampton Biomedical Research Centre (NIHR203319). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.