The structure and relative/absolute configuration of the C-15:0 iso-branched fatty acyl 1,6-anhydropyranose 1 isolated from the Australian marine sponge Plakinastrella clathrata have been investigated. Synthesis of the C-16:0 side chain-modified analogues 3 and 4 has enabled the relative configuration of the C-3 lactate moiety to be secured. In a preliminary anti-inflammatory screening, glycolipid 1 exhibited moderate activity in a PGE2 inhibition assay, however, the compound showed no activity in cytotoxicity screening using 3T3 and P388 cell lines.
Journal article
Structure and stereochemistry of an anti-inflammatory anhydrosugar from the Australian marine sponge Plakinastrella clathrata and the synthesis of two analogues
Tetrahedron, Vol.69(37), pp.8074-8079
2013
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Source: InCites
Abstract
Details
- Title
- Structure and stereochemistry of an anti-inflammatory anhydrosugar from the Australian marine sponge Plakinastrella clathrata and the synthesis of two analogues
- Creators
- Peter L Katavic - University of QueenslandKen WL Yong - University of QueenslandJoel N Herring - University of QueenslandMyrna A Deseo - Southern Cross UniversityJoanne T Blanchfield - University of QueenslandVito Ferro - University of QueenslandMary J Garson - University of Queensland
- Publication Details
- Tetrahedron, Vol.69(37), pp.8074-8079
- Identifiers
- 1698; 991012820967802368
- Academic Unit
- Southern Cross Plant Science
- Resource Type
- Journal article