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Skeletal muscle metabolomic responses to endurance and resistance training in rats under chronic unpredictable mild stress
Journal article   Open access   Peer reviewed

Skeletal muscle metabolomic responses to endurance and resistance training in rats under chronic unpredictable mild stress

X Liu, X Xue, J Tian, X Qin, S Zhou, A Chen and Y Han
International Journal of Environmental Research and Public Health, Vol.18(4), 1645
2021
DOI: https://doi.org/10.3390/ijerph18041645
PMID: 33572176
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Abstract

depression 1H-NMR skeletal muscle metabolomics Expanding Knowledge in the Medical and Health Sciences Exercise
The objectives of this study were to compare the antidepressant effects between endurance and resistance exercise for optimizing interventions and examine the metabolomic changes in different types of skeletal muscles in response to the exercise, using a rat model of chronic unpredictable mild stress (CUMS)-induced depression. There were 32 male Sprague-Dawley rats randomly divided into a control group (C) and 3 experimental groups: CUMS control (D), endurance exercise (E), and resistance exercise (R). Group E underwent 30 min treadmill running, and group R performed 8 rounds of ladder climbing, 5 sessions per week for 4 weeks. Body weight, sucrose preference, and open field tests were performed pre and post the intervention period for changes in depressant symptoms, and the gastrocnemius and soleus muscles were sampled after the intervention for metabolomic analysis using the

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