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Sex- and age-related differences in autistic behaviours in children with neurofibromatosis type 1
Journal article   Peer reviewed

Sex- and age-related differences in autistic behaviours in children with neurofibromatosis type 1

Anita K. Chisholm, Francesca Lami, Kristina M. Haebich, Alex Ure, Amanda Brignell, Tiba Maloof, Natalie A. Pride, Karin S. Walsh, Alice Maier, Melissa Rouel, …
Journal of autism and developmental disorders
20/04/2022
DOI: https://doi.org/10.1007/s10803-022-05571-6
PMID: 35445370

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Abstract

Psychology Psychology, Developmental Social Sciences Neurofbromatosis type 1 Autism Sex differences Age related differences Children
This study investigated sex and age differences in autistic behaviours in children with neurofibromatosis type 1 (NF1) who scored within the clinical range on the Social Responsiveness Scale - Second Edition (T score >= 60). Thirty-four males and 28 females (3-16 years) were assessed with the Autism Diagnostic Observation Schedule - Second Edition and Autism Diagnostic Interview - Revised. Across both measures, males exhibited greater social communication deficits relative to females. Age-related abatement of social communication difficulties was observed for males but not females. Conversely, no sex differences were found for restricted/repetitive behaviours, which were stable over time for both males and females. The findings are discussed within the context of broader neurodevelopmental considerations that are common in NF1.

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