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Serum metabolomic responses to aerobic exercise in rats under chronic unpredictable mild stress3.81 MB
Published (Version of record)CC BY V4.0, Open Access
Published (Version of record)CC BY V4.0, Open
Journal article
Serum metabolomic responses to aerobic exercise in rats under chronic unpredictable mild stress
Scientific Reports, Vol.12, 4888
01/01/2022
PMID: 35318439
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Abstract
This study analyzed the effects of aerobic exercise on endogenous serum metabolites in response to chronic unpredictable mild stress (CUMS) using a rat model, aiming to identify the metabolic regulatory pathways involved in the antidepressant effect resulted from a 28-day treadmill aerobic exercise intervention. The animals were randomly divided into four groups (n = 8): normal control, normal with aerobic exercise, CUMS control, and CUMS with aerobic exercise. Body weight, sucrose preference and open field tests were performed weekly during the intervention period for changes in depressant symptoms. Serum metabolic profiles obtained by using the LC–MS/MS metabolomics were analyzed to explore the regulatory mechanism for the effect of the aerobic exercise on depression. Behavior tests showed that the aerobic exercise resulted in a significant improvement in depression-like behavior in the CUMS rats. A total of 21 differential metabolites were identified as being associated with depression in serum metabolic profile, of which the aerobic exercise significantly modulated 15, mainly related to amino acid metabolism and energy metabolism. Collectively, this is the first study that LC–MS/MS techniques were used to reveal the modulatory effects of aerobic exercise on the serum metabolic profile of depressed rats and the findings further enriched our understanding of potential mechanisms of aerobic exercise interventions on depression.
Details
- Title
- Serum metabolomic responses to aerobic exercise in rats under chronic unpredictable mild stress
- Creators
- Xiangyu Liu - Shanxi UniversityYumei Han - Shanxi UniversityShi Zhou - Southern Cross UniversityJunsheng Tian - Shanxi UniversityXuemei Qin - Shanxi UniversityCui Ji - Shanxi UniversityWeidi Zhao - Shanxi UniversityAnping Chen - Shanxi University
- Publication Details
- Scientific Reports, Vol.12, 4888
- Publisher
- Nature Publishing Group
- Grant note
- Tis work was supported by the National Natural Science Foundation of China (82074147) and the Basic Research Program of Shanxi Province, China (20210302124027).
- Identifiers
- 991013004998802368
- Copyright
- Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Academic Unit
- Human Sciences; Faculty of Health
- Language
- English
- Resource Type
- Journal article