Journal article
Selective anti-proliferative activities of Carica papaya leaf juice extracts against prostate cancer
Biomedicine & pharmacotherapy, Vol.89, pp.515-523
2017
PMID: 28249253
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Source: InCites
Abstract
Prostate cancer (PCa) is the leading cause of cancer related deaths in men. Carica papaya is a popular tropical plant that has been traditionally used for its nutritional and medicinal properties.
We investigated the anti-proliferative responses of papaya leaf juice (LJP) and its various extracts (“biological”- in vitro digested, “physical”- size exclusion, and “chemical”-solvent extraction) on a range of cell lines representing benign hyperplasia, tumorigenic and normal cells of prostate origin.
Time course analysis (by 24h, 48h and 72h) of LJP (1–0.1mg/mL) before and after in vitro digestion, and of molecular weight based fractions of LJP showed anti-proliferative responses. The medium polarity fraction of LJP (0.03–0.003mg/mL) after 72h exposure showed potent growth inhibitory (IC50=0.02–0.07mg/mL) and cytotoxic activities on all prostate cells, with the exception of the normal (RWPE-1 and WPMY-1) cells. Flow cytometry analysis showed S phase cell cycle arrest and apoptosis as a possible mechanism for these activities. Medium polar fraction of LJP also inhibited migration and adhesion of metastatic PC-3 cells.
This is the first report suggesting selective anti-proliferative and anti-metastatic attributes of LJP extract against prostatic diseases, including PCa.
Details
- Title
- Selective anti-proliferative activities of Carica papaya leaf juice extracts against prostate cancer
- Creators
- Saurabh Pandey - University of QueenslandCarina Walpole - Queensland University of TechnologyPeter J Cabot - University of QueenslandPaul N Shaw - University of QueenslandJyotsna Batra - Queensland University of TechnologyAmitha K Hewavitharana (Corresponding Author) - University of Queensland
- Publication Details
- Biomedicine & pharmacotherapy, Vol.89, pp.515-523
- Publisher
- Elsevier Masson SAS
- Identifiers
- 991012893698902368
- Academic Unit
- Science; Faculty of Science and Engineering; Southern Cross Plant Science
- Language
- English
- Resource Type
- Journal article