Saskatoon Berry Amelanchier alnifolia Regulates Glucose Metabolism and Improves Cardiovascular and Liver Signs of Diet-Induced Metabolic Syndrome in Rats

Ryan du Preez; Stephen Wanyonyi; Peter Mouatt; Sunil K Panchal; Lindsay Brown

doi:10.3390/nu12040931

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Saskatoon Berry Amelanchier alnifolia Regulates Glucose Metabolism and Improves Cardiovascular and Liver Signs of Diet-Induced Metabolic Syndrome in Rats

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Saskatoon Berry Amelanchier alnifolia Regulates Glucose Metabolism and Improves Cardiovascular and Liver Signs of Diet-Induced Metabolic Syndrome in Rats

Ryan du Preez, Stephen Wanyonyi, Peter Mouatt, Sunil K Panchal and Lindsay Brown

Nutrients, Vol.12(4), 931

27/03/2020

DOI: https://doi.org/10.3390/nu12040931

PMID: 32230955

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Abstract

metabolic syndrome

Amelanchier alnifolia

inflammation

Saskatoon berry

anthocyanin

flavonoid

obesity

Saskatoon berry (Amelanchier alnifolia) is a potential functional food containing anthocyanins and flavonols, as well as ellagitannins and phenolic acids. We have determined the potential therapeutic effects of Saskatoon berry in diet-induced metabolic syndrome. Nine- to ten-week-old male Wistar rats were randomly assigned to four groups. Two groups were fed on control diets, either corn starch (C) or high-carbohydrate, high-fat diet (H) respectively, for 16 weeks. Two further groups were fed on C or H diet for 16 weeks with Saskatoon berry powder added to the diet for the final 8 weeks (CSSK, HSSK). After 16 weeks, H rats showed symptoms of metabolic syndrome, including increased body weight, visceral adiposity, systolic blood pressure, cardiac fibrosis, plasma concentrations of triglycerides and non-esterified fatty acids, and plasma activities of alanine transaminase and aspartate transaminase. Saskatoon berry intervention normalised body weight and adiposity, improved glucose tolerance, decreased systolic blood pressure, improved heart and liver structure and function with decreased infiltration of inflammatory cells, and decreased plasma total cholesterol. Further, Saskatoon berry normalised liver expression of hexokinase 1 and glycogen phosphorylase and increased glucose 6-phosphatase relative to H rats. These results suggest that Saskatoon berry regulates glycolysis, gluconeogenesis and glycogenesis to improve metabolic syndrome.

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Title: Saskatoon Berry Amelanchier alnifolia Regulates Glucose Metabolism and Improves Cardiovascular and Liver Signs of Diet-Induced Metabolic Syndrome in Rats
Creators: Ryan du Preez (Author) - School of Health and Wellbeing, University of Southern Queensland, Toowoomba, QLD 4350, Australia
Stephen Wanyonyi (Author) - Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD 4350, Australia
Peter Mouatt (Author) - Southern Cross Plant Science, Southern Cross University, Lismore, NSW 2480, Australia
Sunil K Panchal (Author) - Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD 4350, Australia
Lindsay Brown (Author) - School of Health and Wellbeing, University of Southern Queensland, Toowoomba, QLD 4350, Australia
Publication Details: Nutrients, Vol.12(4), 931
Publisher: Switzerland
Grant note: SRF09 / University of Southern Queensland
Identifiers: 991012925669602368
Academic Unit: Southern Cross Plant Science
Language: English
Resource Type: Journal article

Saskatoon Berry Amelanchier alnifolia Regulates Glucose Metabolism and Improves Cardiovascular and Liver Signs of Diet-Induced Metabolic Syndrome in Rats

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