Journal article
Salivary cortisol reveals overt and hidden anxiety in survivors of childhood cancer attending clinic
Journal of affective disorders, Vol.240, pp.105-112
11/2018
PMID: 30059936
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Source: InCites
Abstract
Background
Symptoms of anxiety may arise from fear of cancer recurrence and memories of traumatic experiences during treatment. This study aimed to identify changes in mental health and cortisol, a biological marker of stress, associated with oncology surveillance clinic attendance.
Methods
Adolescent and young adult (AYA) survivors of childhood cancer (aged 12–30 years, N = 46) attending a survivorship clinic were recruited. The State-Trait Anxiety Inventory, an anxiety self-rating and open answer question, and salivary cortisol collections were completed two weeks before and one day before clinic, on clinic day and two weeks after.
Results
Trait anxiety scores were consistent with the normal population. State anxiety scores two weeks after clinic were significantly lower than baseline (p = 0.02). Cortisol diurnal slopes were flatter than baseline after clinic (p = 0.02). Evening cortisol levels were significantly higher than baseline two weeks post clinic (p = 0.02).
Limitations
Combined results from biological and psychometric assessments can be difficult to interpret. Larger cohorts will further delineate cortisol pathway activity and distress in AYA cancer survivors.
Conclusions
Psychometric evidence indicates that AYA survivors of childhood cancer perceive themselves to be less anxious after a survivorship clinic visit. Biological evidence, however, indicates a dysregulation of the hypothalamic-pituitary-adrenal axis which may be linked to clinic attendance. Weak correlations suggest that cortisol may not be a reliable indicator of self-perceived anxiety. This may be due to confounding lifestyle factors influencing the stress response or potential ‘coping strategies’ developed during past treatment experience which may, hypothetically, have masked self-perceived anxiety.
Details
- Title
- Salivary cortisol reveals overt and hidden anxiety in survivors of childhood cancer attending clinic
- Creators
- Mazen Amatoury - Children's Hospital at WestmeadAnn M. Maguire - Children's Hospital at WestmeadJake Olivier - University of New South WalesBelinda Barton - Children's Hospital at WestmeadMelissa Gabriel - Children's Hospital at WestmeadLuciano Dalla-Pozza - Children's Hospital at WestmeadKatharine S. Steinbeck - Children's Hospital at WestmeadRobert A. Battisti - Children's Hospital at Westmead
- Publication Details
- Journal of affective disorders, Vol.240, pp.105-112
- Publisher
- Elsevier B.V
- Identifiers
- 991013093609302368
- Copyright
- Crown Copyright © 2018 Published by Elsevier B.V. All rights reserved.
- Academic Unit
- Faculty of Health
- Language
- English
- Resource Type
- Journal article