Renoprotection Induced by Aerobic Training Is Dependent on Nitric Oxide Bioavailability in Obese Zucker Rats

Rodrigo Vanerson Passos Neves; Hugo de Luca Corrêa; Ivo Vieira de Sousa Neto; Michel Kendy Souza; Fernando Costa; Anderson Sola Haro; Lysleine Alves Deus; Andrea Lucena Reis; Herbert Gustavo Simões; Rosângela Vieira Andrade; Cláudio Oliveira Assumpção; Whitley Stone; Jonato Prestes; Elaine Cristina Vieira; Rita de Cássia Marquetti Durigan; Vinicius Cruzat; Thiago S Rosa

doi:10.1155/2021/3683796

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Renoprotection Induced by Aerobic Training Is Dependent on Nitric Oxide Bioavailability in Obese Zucker Rats

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Renoprotection Induced by Aerobic Training Is Dependent on Nitric Oxide Bioavailability in Obese Zucker Rats

Rodrigo Vanerson Passos Neves, Hugo de Luca Corrêa, Ivo Vieira de Sousa Neto, Michel Kendy Souza, Fernando Costa, Anderson Sola Haro, Lysleine Alves Deus, Andrea Lucena Reis, Herbert Gustavo Simões, Rosângela Vieira Andrade, …

Oxidative medicine and cellular longevity, Vol.2021, pp.1-17

28/09/2021

DOI: https://doi.org/10.1155/2021/3683796

PMID: 34621463

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Abstract

Animals

Biological Availability

Blood Glucose - metabolism

Enzyme Inhibitors - pharmacology

Kidney - metabolism

Male

Mitochondria - metabolism

Models, Animal

NG-Nitroarginine Methyl Ester - pharmacology

Nitric Oxide - metabolism

Nitric Oxide Synthase - antagonists & inhibitors

Obesity - metabolism

Oxidation-Reduction - drug effects

Physical Conditioning, Animal

Rats

Rats, Zucker

Reactive Oxygen Species - metabolism

Signal Transduction - drug effects

Aerobic training (AT) promotes several health benefits that may attenuate the progression of obesity associated diabetes. Since AT is an important nitric oxide (NO-) inducer mediating kidney-healthy phenotype, the present study is aimed at investigating the effects of AT on metabolic parameters, morphological, redox balance, inflammatory profile, and vasoactive peptides in the kidney of obese-diabetic Zucker rats receiving L-NAME (N(omega)-nitro-L-arginine methyl ester). Forty male Zucker rats (6 wk old) were assigned into four groups (, each): sedentary lean rats (CTL-Lean), sedentary obese rats (CTL-Obese), AT trained obese rats without blocking nitric oxide synthase (NOS) (Obese+AT), and obese-trained with NOS block (Obese+AT+L-NAME). AT groups ran 60 min in the maximal lactate steady state (MLSS), five days/wk/8 wk. Obese+AT rats improved glycemic homeostasis, SBP, aerobic capacity, renal mitochondria integrity, redox balance, inflammatory profile (e.g., TNF-α, CRP, IL-10, IL-4, and IL-17a), and molecules related to renal NO- metabolism (klotho/FGF23 axis, vasoactive peptides, renal histology, and reduced proteinuria). However, none of these positive outcomes were observed in CTL-Obese and Obese+AT+L-NAME () groups. Although Obese+AT+L-NAME lowered BP (compared with CTL-Obese; ), renal damage was observed after AT intervention. Furthermore, AT training under conditions of low NO- concentration increased signaling pathways associated with ACE-2/ANG1-7/MASr. We conclude that AT represents an important nonpharmacological intervention to improve kidney function in obese Zucker rats. However, these renal and metabolic benefits promoted by AT are dependent on NO- bioavailability and its underlying regulatory mechanisms.

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Title: Renoprotection Induced by Aerobic Training Is Dependent on Nitric Oxide Bioavailability in Obese Zucker Rats
Creators: Rodrigo Vanerson Passos Neves - Graduate Program in Physical Education, Catholic University of Brasília, Brasília, Brazil
Hugo de Luca Corrêa - Graduate Program in Physical Education, Catholic University of Brasília, Brasília, Brazil
Ivo Vieira de Sousa Neto - Laboratory of Molecular Analysis, Graduate Program of Sciences and Technology of Health, Universidade de Brasília, Distrito Federal, Brazil
Michel Kendy Souza - Department of Nephrology, Federal University of São Paulo, São Paulo, Brazil
Fernando Costa - Graduate Program in Physical Education, Catholic University of Brasília, Brasília, Brazil
Anderson Sola Haro - Department of Nephrology, Federal University of São Paulo, São Paulo, Brazil
Lysleine Alves Deus - Graduate Program in Physical Education, Catholic University of Brasília, Brasília, Brazil
Andrea Lucena Reis - Graduate Program in Physical Education, Catholic University of Brasília, Brasília, Brazil
Herbert Gustavo Simões - Graduate Program in Physical Education, Catholic University of Brasília, Brasília, Brazil
Rosângela Vieira Andrade - Graduate Program in Genomic Sciences and Biotechnology, Universidade Católica de Brasília, Brasília, Brazil
Cláudio Oliveira Assumpção - Department of Physical Education, Federal University of Ceará, Ceará, Brazil
Whitley Stone - School of Kinesiology, Recreation, and Sport, Western Kentucky University, Bowling Green, KY, USA
Jonato Prestes - Graduate Program in Physical Education, Catholic University of Brasília, Brasília, Brazil
Elaine Cristina Vieira - Graduate Program in Physical Education, Catholic University of Brasília, Brasília, Brazil
Rita de Cássia Marquetti Durigan - Laboratory of Molecular Analysis, Graduate Program of Sciences and Technology of Health, Universidade de Brasília, Distrito Federal, Brazil
Vinicius Cruzat - Torrens University Australia
Thiago S Rosa - Graduate Program in Physical Education, Catholic University of Brasília, Brasília, Brazil
Publication Details: Oxidative medicine and cellular longevity, Vol.2021, pp.1-17
Publisher: Hindawi
Identifiers: 991013071409202368
Copyright: Copyright © 2021 Rodrigo Vanerson Passos Neves et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Academic Unit: Faculty of Health
Language: English
Resource Type: Journal article

Renoprotection Induced by Aerobic Training Is Dependent on Nitric Oxide Bioavailability in Obese Zucker Rats

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