Journal article
Regulatory principles in metabolism – then and now
Biochem. J, Vol.473(13), pp.1845-1857
07/2016
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Source: InCites
Abstract
The importance of metabolic pathways for life and the nature of participating reactions have challenged physiologists and biochemists for over a hundred years. Eric Arthur Newsholme contributed many original hypotheses and concepts to the field of metabolic regulation, demonstrating that metabolic pathways have a fundamental thermodynamic structure and that near identical regulatory mechanisms exist in multiple species across the animal kingdom. His work at Oxford University from the 1970s to 1990s was groundbreaking and led to better understanding of development and demise across the lifespan as well as the basis of metabolic disruption responsible for the development of obesity, diabetes and many other conditions. In the present review we describe some of the original work of Eric Newsholme, its relevance to metabolic homoeostasis and disease and application to present state-of-the-art studies, which generate substantial amounts of data that are extremely difficult to interpret without a fundamental understanding of regulatory principles. Eric's work is a classical example of how one can unravel very complex problems by considering regulation from a cell, tissue and whole body perspective, thus bringing together metabolic biochemistry, physiology and pathophysiology, opening new avenues that now drive discovery decades thereafter.
Details
- Title
- Regulatory principles in metabolism – then and now
- Creators
- Rui Curi - University of São PauloGabriel Nasri Marzuca-Nassr - University of São PauloHilton Kenji Takahashi - University of São PauloSandro Massao Hirabara - University of São PauloVinicius Cruzat - University of São PauloMauricio Krause - Universidade Federal do Rio Grande do SulPaulo Ivo Homem de Bittencourt - Universidade Federal do Rio Grande do Sul
- Publication Details
- Biochem. J, Vol.473(13), pp.1845-1857
- Publisher
- Portland Press
- Identifiers
- 991013071411702368
- Copyright
- © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society
- Academic Unit
- Faculty of Health
- Language
- English
- Resource Type
- Journal article