Journal article
Randomized controlled trials investigating the relationship between dietary pattern and high-sensitivity C-reactive protein: a systematic review
Nutrition reviews, Vol.77(6), pp.363-375
06/2019
PMID: 31222367
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Source: InCites
Abstract
Context
Elevated serum concentration of high-sensitivity C-reactive protein (hsCRP), a biomarker of systemic inflammation, is associated with increased risk for coronary heart disease (CHD) and cardiovascular events (CVEs). Because elevations in hsCRP often occur in parallel with elevations in low-density lipoproteins (LDLs) and both biomarkers are reduced by hydroxymethylglutaryl-CoA reductase inhibitors (ie, statin drugs), efforts to determine nonpharmacological treatments to lower hsCRP remain limited. Dietary modifications in particular are rarely discussed as viable clinical interventions yet merit investigation.
Objective
This systematic review was performed to assess the relationship between dietary patterns and hsCRP among individuals enrolled in randomized controlled trials.
Data Sources
National Library of Medicine (ie, MEDLINE) and Google Scholar searches were performed using the search terms “C-reactive protein,” “CRP,” “dietary pattern,” and/or “diet” to identify articles published between January 2000 and October 2017.
Data Extraction
Data were extracted and analyzed according to PRISMA guidelines. Identified abstracts were reviewed and cross-referenced for relevance to dietary pattern. Full-text manuscripts were then abstracted for their principal findings. Fifty-six manuscripts met inclusion criteria for detailed review.
Results
Clinical trials of dietary interventions to reduce hsCRP are mixed in quality and findings. Several specific dietary patterns may reduce hsCRP, including low-fat, low-carbohydrate, Mediterranean, Portfolio, Paleolithic, and the Dietary Approaches to Stop Hypertension (DASH) diets. However, results were mixed for the majority of dietary patterns (eg, low-glycemic load diets).
Conclusion
Information available to date suggests that a wide variety of dietary patterns may impact serum hsCRP, although studies are mixed in quality. The efficacy of dietary patterns for the treatment of elevated hsCRP as a strategy for primary prevention of CHD may be best elucidated in randomized clinical trials in healthy participants with elevated hsCRP but low or normal traditional risk factors, or by using more aggressive dietary modifications in high-risk patients. Given current incidence and prevalence of CHD risk factors, additional randomized controlled trials of this type are justified and needed.
Details
- Title
- Randomized controlled trials investigating the relationship between dietary pattern and high-sensitivity C-reactive protein: a systematic review
- Creators
- Courtney K. Pickworth - National University of Natural MedicineDavid A. Deichert - Seattle Health Arts Center, Seattle, Washington, USA.Jamie Corroon - National University of Natural MedicineRyan D. Bradley - University of California, San Diego
- Publication Details
- Nutrition reviews, Vol.77(6), pp.363-375
- Publisher
- Oxford Univ Press
- Number of pages
- 13
- Identifiers
- 991013036323502368
- Copyright
- © The Author(s) 2019. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model).
- Academic Unit
- National Centre for Naturopathic Medicine
- Language
- English
- Resource Type
- Journal article