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Psychiatric comorbidity and in-hospital mortality in patients hospitalized for physical conditions in Germany
Journal article   Peer reviewed

Psychiatric comorbidity and in-hospital mortality in patients hospitalized for physical conditions in Germany

Karel Kostev, Benjamin Landré, Dong Keon Yon, Josep Maria Haro, Razak M. Gyasi, André Hajek and Louis Jacob
Journal of psychiatric research, Vol.182, pp.489-496
02/2025
DOI: https://doi.org/10.1016/j.jpsychires.2025.01.049
PMID: 39893786
Appears in  Recent National Centre for Naturopathic Medicine Publications

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Abstract

cross-sectional study epidemiology Germany hospital mortality psychiatric comorbidity
Objective: To investigate the association between psychiatric comorbidity and in-hospital mortality in patients hospitalized for physical conditions in Germany. Methods: This retrospective study used data from the hospital database of IQVIA (Frankfurt, Germany). Adults with a psychiatric disorder as a secondary diagnosis at hospital admission were matched (1:3) to those without a psychiatric disorder using a propensity score based on age, sex, hospital department, and primary diagnosis. Diagnoses of psychiatric and physical disorders relied on the ICD-10 classification. Associations between psychiatric comorbidity and in-hospital mortality were studied using logistic regression. Results: There were 36,796 patients with (mean [SD] age 66.2 [14.7] years; 53.4% men) and 110,388 patients without psychiatric comorbidity included in the study (mean [SD] age 66.1 [15.1] years; 51.9% men). Overall, no statistical association was observed between psychiatric comorbidity and in-hospital mortality (OR=1.00, 95% CI=0.95-1.05). However, there was a positive and significant relationship in people aged ≤70 years and men, whereas a negative association was observed for those aged >80 years and women. Conclusions: Psychiatric comorbidity was associated with increased in-hospital mortality in patients aged ≤70 years and men in hospitals in Germany. Further research is warranted to corroborate these findings in other countries.

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