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Published (Version of record)CC BY V4.0, Open Access
Published (Version of record)CC BY V4.0, Open
Journal article
Probiotics Evaluation in Oncological Surgery: A Systematic Review of 36 Randomized Controlled Trials Assessing 21 Diverse Formulations
Current Oncology (Toronto), Vol.28(6), pp.5192-5214
07/12/2021
PMCID: PMC8700227
PMID: 34940074
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Source: InCites
Abstract
Background: Objectives were to evaluate probiotics safety and efficacy in oncological surgery. Methods: Systematic review methodology guided by Cochrane, PRISMA, SWiM, and CIOMS. Protocol registered on PROSPERO (CRD42018086168). Results: 36 RCTs (on 3305 participants) and 6 nonrandomized/observational studies were included, mainly on digestive system cancers. There was evidence of a beneficial effect on preventing infections, with 70% of RCTs’ (21/30) direction of effect favoring probiotics. However, five RCTs (17%) favored controls for infections, including one trial with RR 1.57 (95% CI: 0.79, 3.12). One RCT that changed (balanced) its antibiotics protocol after enrolling some participants had mortality risk RR 3.55 (95% CI: 0.77, 16.47; 7/64 vs. 2/65 deaths). The RCT identified with the most promising results overall administered an oral formulation of Lactobacillus acidophilus LA-5 + Lactobacillus plantarum + Bifidobacterium lactis BB-12 + Saccharomyces boulardii. Methodological quality appraisals revealed an overall substantial risk-of-bias, with only five RCTs judged as low risk-of-bias. Conclusions: This large evidence synthesis found encouraging results from most formulations, though this was contrasted by potential harms from a few others, thus validating the literature that “probiotics” are not homogeneous microorganisms. Given microbiome developments and infections morbidity, further high-quality research is warranted using those promising probiotics identified herein
Details
- Title
- Probiotics Evaluation in Oncological Surgery: A Systematic Review of 36 Randomized Controlled Trials Assessing 21 Diverse Formulations
- Creators
- Elise Cogo - Canadian College of Naturopathic MedicineMohamed Elsayed - Canadian College of Naturopathic MedicineVivian Liang - Canadian College of Naturopathic MedicineKieran Cooley - Canadian College of Naturopathic MedicineChristilynn Guerin - Canadian College of Naturopathic MedicineAthanasios Psihogios - Canadian College of Naturopathic MedicinePeter Papadogianis - Canadian College of Naturopathic Medicine
- Publication Details
- Current Oncology (Toronto), Vol.28(6), pp.5192-5214
- Publisher
- MDPI AG
- Identifiers
- 991012987891502368
- Copyright
- © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Academic Unit
- Faculty of Science and Engineering; National Centre for Naturopathic Medicine; Science
- Language
- English
- Resource Type
- Journal article