Prevalence of Chronic Hepatitis B Virus Infection in Sierra Leone, 1997–2022: A Systematic Review and Meta-Analysis

George Yendawa; Gi-Ming Wang; Peter Bai James; Samuel P.E. Massaquoi; Sahr A Yendewa; Manal Ghazawi; Lawrence S Babawo; Ponsiano Ocama; James B W Russell; Gibrilla F Deen; Foday Sahr; Mustapha Kabba; Curtis Tatsuoka; Sulaiman Lakoh; Robert A Salata

doi:10.4269/ajtmh.22-0711

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Prevalence of Chronic Hepatitis B Virus Infection in Sierra Leone, 1997–2022: A Systematic Review and Meta-Analysis

Journal article

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Prevalence of Chronic Hepatitis B Virus Infection in Sierra Leone, 1997–2022: A Systematic Review and Meta-Analysis

George Yendawa, Gi-Ming Wang, Peter Bai James, Samuel P.E. Massaquoi, Sahr A Yendewa, Manal Ghazawi, Lawrence S Babawo, Ponsiano Ocama, James B W Russell, Gibrilla F Deen, …

The American journal of tropical medicine and hygiene : official journal of the American Society of Tropical Medicine and Hygiene, Vol.109(1), pp.105-114

05/07/2023

DOI: https://doi.org/10.4269/ajtmh.22-0711

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Abstract

Hepatitis B virus

Sierra Leone

Prevalence

Systematic Review and Meta-analysis

Infectious diseases

Epidemiology

Hepatitis B virus (HBV) infection is a major public health problem in Sierra Leone, yet reliable estimates of cases are lacking. This study aimed to provide an estimate of the national prevalence of chronic HBV infection in the general population and select groups in Sierra Leone. We used the electronic databases PubMed/MEDLINE, Embase, Scopus, ScienceDirect, Web of Science, Google Scholar, and African Journals Online to systematically review articles reporting hepatitis B infection surface antigen seroprevalence estimates in Sierra Leone during 1997–2022. We estimated pooled HBV seroprevalence rates and assessed potential sources of heterogeneity. Of 546 publications screened, 22 studies with a total sample size of 107,186 people were included in the systematic review and meta-analysis. The pooled prevalence of chronic HBV infection was 13.0% (95% CI, 10.0–16.0) (I2 = 99%; Pheterogeneity < 0.01). During the study period, the HBV prevalence rates were as follows: 17.9% (95% CI, 6.7–39.8) before 2015, 13.3% (95% CI, 10.4–16.9) during 2015–2019, and 10.7% (95% CI, 7.5–14.9) during 2020–2022. The use of the 2020–2022 HBV prevalence estimates corresponded to 870,000 cases of chronic HBV infection (uncertainty interval, 610,000–1,213,000), or approximately one in nine people. The highest HBV seroprevalence estimates were among adolescents aged 10–17 years (17.0%; 95% CI, 8.8–30.5), Ebola survivors (36.8%; 95% CI, 26.2–48.8), people living with HIV (15.9%; 95% CI, 10.6–23.0), and those in the Northern Province (19.0%; 95% CI, 6.4–44.7) and Southern Province (19.7%; 95% CI, 10.9–32.8) regions. These findings may help inform national HBV program implementation in Sierra Leone.

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Title: Prevalence of Chronic Hepatitis B Virus Infection in Sierra Leone, 1997–2022: A Systematic Review and Meta-Analysis
Creators: George Yendawa - Department of Medicine, Case Western Reserve University School of Medicine,
Gi-Ming Wang - Case Western Reserve University School of Medicine
Peter Bai James (Author) - Southern Cross University
Samuel P.E. Massaquoi - Ministry of Health and Sanitation
Sahr A Yendewa - Ministry of Health and Sanitation
Manal Ghazawi - KnowHep Foundation
Lawrence S Babawo - Njala University
Ponsiano Ocama - Makerere University
James B W Russell - University of Sierra Leone
Gibrilla F Deen - University of Sierra Leone
Foday Sahr - Makerere University
Mustapha Kabba - Ministry of Health and Sanitation
Curtis Tatsuoka - Department of Medicine, Case Western Reserve University School of Medicine,
Sulaiman Lakoh - University of Sierra Leone
Robert A Salata - Case Western Reserve University School of Medicine
Publication Details: The American journal of tropical medicine and hygiene : official journal of the American Society of Tropical Medicine and Hygiene, Vol.109(1), pp.105-114
Publisher: American Society of Tropical Medicine and Hygiene
Grants: Roe Green Center for Travel Medicine and Global Health/University Hospitals Cleveland Medical Center, J0713, Roe Green Center for Travel Medicine and Global Health/University Hospitals Cleveland Medical Center
University Hospitals Minority Faculty Career Development Award, P0603, University Hospitals Cleveland Medical Center
National Institutes of Health (NIH)/AIDS Clinical Trials Group (ACTG), 5UM1AI068636-15, National Institutes of Health/AIDS Clinical Trials Group
National Institutes of Health (NIH)/AIDS Clinical Trials Group (ACTG), AI068636 (1560GYD212), National Institutes of Health/AIDS Clinical Trials Group
Identifiers: 991013118213802368
Academic Unit: National Centre for Naturopathic Medicine
Language: English
Resource Type: Journal article

Prevalence of Chronic Hepatitis B Virus Infection in Sierra Leone, 1997–2022: A Systematic Review and Meta-Analysis

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