Journal article
Prenatal risk factors for severe retinopathy of prematurity among very preterm infants of the Australian and New Zealand Neonatal Network
Pediatrics, Vol.115(4), pp.990-996
2005
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Source: InCites
Abstract
<p><strong>Objective.</strong> To identify prenatal and perinatal risk factors for clinically severe (stage 3 or 4) retinopathy of prematurity (ROP).</p>
<p><strong>Methods</strong>. Data were collected prospectively as part of the ongoing Australian and New Zealand Neonatal Network audit of high-risk infants (birth weight of <1500 g or gestational age [GA] of <32 weeks) admitted to a level III neonatal unit in Australia or New Zealand. Prenatal and perinatal factors to 1 minute of age were examined for the subset of infants with GA of <29 weeks who survived to 36 weeks’ postmenstrual age and were examined for ROP (n = 2105). The factors significantly associated with stage 3 or 4 ROP were entered into a multivariate logistic regression model.</p>
<p><strong>Results.</strong> Two-hundred three infants (9.6%) had stage 3 or more ROP. Prematurity was the dominant risk factor, with infants with GA of <25 weeks having 20 times greater odds of severe ROP than infants with GA of 28 weeks. Birth weight for GA also had a “dose-response” effect; the more growth-restricted infants had greater risk, with infants below the 3rd percentile of weight for GA having 4 times greater odds of severe ROP than those between the 25th and 75th percentiles. Male gender was also a significant risk factor (odds ratio: 1.73; 95% confidence interval: 1.25–2.40).</p>
<p><strong>Conclusions.</strong> These data, for a large, essentially population-based cohort, suggest that factors related to the degree of immaturity, intrauterine growth restriction, and male gender contribute to severe ROP.</p>
Details
- Title
- Prenatal risk factors for severe retinopathy of prematurity among very preterm infants of the Australian and New Zealand Neonatal Network
- Creators
- Brian A Darlow - hristchurch School of Medicine and Health ScienceJolie L HutchinsonDavid J Henderson-SmartDeborah A Donoghue - University of SydneyJudy M SimpsonNicholas J Evans
- Publication Details
- Pediatrics, Vol.115(4), pp.990-996
- Identifiers
- 1073; 991012820791402368
- Academic Unit
- Gnibi College of Indigenous Australian Peoples
- Resource Type
- Journal article