Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial

Kara N. Fitzgerald; Romilly Hodges; Douglas Hanes; Emily Stack; David Cheishvili; Moshe Szyf; Janine Henkel; Melissa W. Twedt; Despina Giannopoulou; Josette Herdell; Sally Logan; Ryan Bradley

doi:10.18632/aging.202913

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Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial

Journal article

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Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial

Kara N. Fitzgerald, Romilly Hodges, Douglas Hanes, Emily Stack, David Cheishvili, Moshe Szyf, Janine Henkel, Melissa W. Twedt, Despina Giannopoulou, Josette Herdell, …

Aging (Albany, NY.), Vol.13(7), pp.9419-9432

12/04/2021

DOI: https://doi.org/10.18632/aging.202913

PMID: 33844651

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Abstract

aging

biological clock

DNA methylation

epigenetic

lifestyle

Research Paper

Manipulations to slow biological aging and extend healthspan are of interest given the societal and healthcare costs of our aging population. Herein we report on a randomized controlled clinical trial conducted among 43 healthy adult males between the ages of 50-72. The 8-week treatment program included diet, sleep, exercise and relaxation guidance, and supplemental probiotics and phytonutrients. The control group received no intervention. Genome-wide DNA methylation analysis was conducted on saliva samples using the Illumina Methylation Epic Array and DNAmAge was calculated using the online Horvath DNAmAge clock (2013). The diet and lifestyle treatment was associated with a 3.23 years decrease in DNAmAge compared with controls (p=0.018). DNAmAge of those in the treatment group decreased by an average 1.96 years by the end of the program compared to the same individuals at the beginning with a strong trend towards significance (p=0.066). Changes in blood biomarkers were significant for mean serum 5-methyltetrahydrofolate (+15%, p=0.004) and mean triglycerides (-25%, p=0.009). To our knowledge, this is the first randomized controlled study to suggest that specific diet and lifestyle interventions may reverse Horvath DNAmAge (2013) epigenetic aging in healthy adult males. Larger-scale and longer duration clinical trials are needed to confirm these findings, as well as investigation in other human populations.

Details

Title: Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial
Creators: Kara N. Fitzgerald - Institute for Functional Medicine, Federal Way, WA 98003, USA.
Romilly Hodges - American Nutrition Association, Hinsdale, IL 60521, USA.
Douglas Hanes - National University of Natural Medicine
Emily Stack - National University of Natural Medicine
David Cheishvili - McGill University
Moshe Szyf - McGill University
Janine Henkel - National University of Natural Medicine
Melissa W. Twedt - National University of Natural Medicine
Despina Giannopoulou - National University of Natural Medicine
Josette Herdell - National University of Natural Medicine
Sally Logan - National University of Natural Medicine
Ryan Bradley - National University of Natural Medicine
Publication Details: Aging (Albany, NY.), Vol.13(7), pp.9419-9432
Publisher: Impact Journals
Identifiers: 991013035756402368
Copyright: © 2021 Fitzgerald et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Academic Unit: National Centre for Naturopathic Medicine
Language: English
Resource Type: Journal article

Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial

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