Journal article
Physical functional capacity of patients with glioma prior to adjuvant radiation: preliminary descriptive study
Neuro-oncology practice, Vol.8(3), pp.290-298
06/2021
PMID: 34055376
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Abstract
Background
Few studies have assessed physical functioning in glioma patients with grade II, III, and IV glioma prior to undergoing adjuvant radiation with or without chemotherapy. The aim of this study was to describe the baseline physical functioning capacity of patients with glioma prior to adjuvant therapy compared to validated cutoffs required to maintain independence.
Methods
This study is a cross-sectional study that recruited patients with grade II, III, and IV glioma (n = 33) undergoing adjuvant radiation with or without chemotherapy. The six-minute walk, thirty-second sit-to-stand, and timed “Up & Go” assessments were used to describe baseline physical functioning. Perceived quality of life from the European Organisation for Research and Treatment of Cancer (EORTC) quality of life questionnaire (QLQ-C30) version 3.0 was used to quantify the quality of life.
Results
Mean distance walked in the six-minute walk test was 416.2 m (SD 137.6 m) with a mean of 12.2 stands (SD 3.4 stands) achieved during the thirty-second sit-to-stand. Median time to complete the timed “Up & Go” assessment was 7 s (interquartile range: 3 s). One-sample t tests suggest walking distance and chair stands were significantly lower than cutoff criterions to maintain independent living, t(32) = −5.96, P < .001, bias-corrected accelerated 95% CI [370.7-460.4], and t(32) = −4.60, P < .01, bias-corrected accelerated 95% CI [11.0-13.4], respectively. Wilcoxon signed-rank test identified significantly shorter median time taken to complete the timed “Up & Go” test compared to the cutoff criterion (z = −4.43, n = 33, P < .01).
Conclusion
This study suggests glioma patient’s aerobic endurance and lower limb strength are below criterion cutoffs recommended to maintain independent living. Timed “Up & Go” scores did not exceed the criterion cutoff, indicating respectable levels of mobility.
Details
- Title
- Physical functional capacity of patients with glioma prior to adjuvant radiation: preliminary descriptive study
- Creators
- Ali Dulfikar - Queensland University of TechnologyEng-Siew Koh - Liverpool HospitalZarnie Lwin - University of QueenslandElizabeth Hovey - UNSW SydneyHaryana Dhillon - University of SydneyJesica Arundell - Liverpool HospitalElizabeth Pinkham - Princess Alexandra HospitalMark B. Pinkham - Princess Alexandra HospitalJustin Holland - Queensland University of TechnologyGabriel Trajano - Queensland University of TechnologyFiona Naumann - Queensland University of Technology
- Publication Details
- Neuro-oncology practice, Vol.8(3), pp.290-298
- Publisher
- Oxford Univ Press
- Number of pages
- 9
- Identifiers
- 991013098102002368
- Copyright
- © The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Neuro-Oncology and the European Association of Neuro-Oncology. All rights reserved.
- Academic Unit
- Faculty of Health
- Language
- English
- Resource Type
- Journal article