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Published (Version of record)CC BY-NC-ND V4.0, Open Access
Published (Version of record)CC BY-NC-ND V4.0, Open
Journal article
Patterns of relapse following hippocampal avoidance prophylactic cranial irradiation for small cell lung carcinoma
Reports of Practical Oncology and Radiotherapy, Vol.26(6), pp.968-975
30/12/2021
PMCID: PMC8726451
PMID: 34992870
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Source: InCites
Abstract
Background: Hippocampal avoidance techniques are an evolving standard of care for patients undergoing cranial irradiation. Our aim was to assess the oncological outcomes and patterns of failure following hippocampal avoidance prophylactic cranial irradiation (HA-PCI) as a standard of care in unselected patients with both limited and extensive stage small cell lung carcinoma.
Materials and methods: Consecutive patients with small cell lung carcinoma with a complete (limited stage) or good partial (extensive stage) response following chemotherapy were eligible to receive HA-PCI, with a total dose of 25 Gray in 10 fractions. All patients had a negative baseline MRI brain scan with gadolinium prior to HA-PCI. Patients had baseline and follow up Common Toxicity Criteria Adverse Event assessments. Following completion of HA-PCI, all patients had three-monthly MRI brain scans with gadolinium until confirmation of intracranial relapse, as well as three-monthly CT of the chest, abdomen and pelvis. Overall and progression-free survival were calculated using the Kaplan-Meier method.
Results: A total of 17 consecutive patients, 9 men and 8 women, with a mean age of 70 years received HA-PCI between May 2016 and June 2020 after completion of their initial chemotherapy. There were no Grade 4 or greater adverse events. No patient had an isolated hippocampal avoidance zone relapse alone; three of 17 patients had multifocal relapses that included the hippocampal avoidance zone.
Conclusion: In our series, there were no hippocampal only relapses and we conclude that HA-PCI is a safe alternative to standard PCI in the setting of small cell lung cancer.
Details
- Title
- Patterns of relapse following hippocampal avoidance prophylactic cranial irradiation for small cell lung carcinoma
- Creators
- Theresa A Cook - Mid North Coast Cancer Institute, Coffs HarbourMatthew R Hoffmann - Mid North Coast Cancer Institute, Port MacquarieAmie J Ross - Mid North Coast Cancer Institute, Coffs HarbourKirsty J Turnbull - Mid North Coast Cancer Institute, Coffs HarbourJustin Westhuyzen - Mid North Coast Cancer Institute, Coffs HarbourNoel J Aherne - Mid North Coast Cancer Institute, Coffs Harbour
- Publication Details
- Reports of Practical Oncology and Radiotherapy, Vol.26(6), pp.968-975
- Publisher
- Wydawnictwo Via Medica
- Identifiers
- 991012987893302368
- Copyright
- © 2021 Greater Poland Cancer Centre. Published by Via Medica. All rights reserved. This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
- Academic Unit
- Coffs Harbour Campus Administration
- Language
- English
- Resource Type
- Journal article