Journal article
Observation of odd–even effect in 1-alcohols through pentapeptide-coated quartz crystal microbalance sensors with molecular docking study
Applied Physics Letters, Vol.126(16), 163701
21/04/2025
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Abstract
The discrimination between odd and even carbon chain molecules is crucial in detecting odd chain metabolites resulting from impaired biosynthetic processes. However, the discrimination of these metabolomes via gas sensors presents significant challenges due to the lack of connection between material–gas interaction and odd–even carbon chain molecules. In this study, a homologous series of 1-alcohols is systematically investigated, quantitatively comparing the measured signals obtained using pentapeptide-coated gas sensors and pentapeptide–gas interactions calculated via molecular docking simulations. The pentapeptide-coated gas sensor exhibits a clear odd–even effect in both absorption and desorption processes, demonstrating better discrimination between odd- and even-numbered carbon compounds. The results indicate that the odd–even effect during the absorption process is closely associated with the hydrophobic interaction between a pentapeptide and a gas molecule, while the interactions affecting the desorption phase may vary depending on the pentapeptide properties. The insights into the molecular interactions involved in the odd–even effect will facilitate the development of materials for detecting odd chain metabolites, which can enhance the accuracy of gas-sensing technologies toward health monitoring applications.
Details
- Title
- Observation of odd–even effect in 1-alcohols through pentapeptide-coated quartz crystal microbalance sensors with molecular docking study
- Creators
- Thuc Anh Ngo - National Institute for Materials ScienceKosuke Minami - National Institute for Materials ScienceTanju Yildirim - National Institute for Materials ScienceKota Shiba - National Institute for Materials ScienceGenki Yoshikawa - National Institute for Materials Science
- Publication Details
- Applied Physics Letters, Vol.126(16), 163701
- Publisher
- AIP Publishing
- Grant note
- Public/Private R&D Investment Strategic Expansion ProgramNIMS Joint Graduate School Program, NIMSPublic/Private R&D Investment Strategic Expansion Program (PRISM), Cabinet Office, Japan
T.A.N. thanks the NIMS Joint Graduate School Program, NIMS. This work was financially supported partially by the Public/Private R&D Investment Strategic Expansion Program (PRISM), Cabinet Office, Japan.
- Identifiers
- 991013330022302368
- Academic Unit
- Faculty of Science and Engineering
- Language
- English
- Resource Type
- Journal article