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Published (Version of record)CC BY V4.0, Open Access
Published (Version of record)CC BY V4.0, Open
Journal article
Novel Detection of Nasty Bugs, Prevention Is Better than Cure
International journal of molecular sciences, Vol.22(1), pp.1-19
12/2020
PMID: 33375709
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Abstract
Hospital-acquired infections (HAIs) are a growing concern around the world. They contribute to increasing mortality and morbidity rates and are an economic threat. All hospital patients have the potential to contract an HAI, but those with weakened or inferior immune systems are at highest risk. Most hospital patients will contract at least one HAI, but many will contract multiple ones. Bacteria are the most common cause of HAIs and contribute to 80-90% of all HAIs, with Staphylococcus aureus, Clostridium difficile, Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae accounting for the majority. Each of these bacteria are highly resistant to antibiotics and can produce a protective film, known as a biofilm, to further prevent their eradication. It has been shown that by detecting and eradicating bacteria in the environment, infection rates can be reduced. The current methods for detecting bacteria are time consuming, non-specific, and prone to false negatives or false positives. Aptamer-based biosensors have demonstrated specific, time-efficient and simple detection, highlighting the likelihood that they could be used in a similar way to detect HAI-causing bacteria.
Details
- Title
- Novel Detection of Nasty Bugs, Prevention Is Better than Cure
- Creators
- Mia Strom - Deakin University (Australia, Geelong)Tamsyn Crowley - Deakin University (Australia, Geelong)Sarah Shigdar - Deakin University (Australia, Geelong)
- Publication Details
- International journal of molecular sciences, Vol.22(1), pp.1-19
- Publisher
- MDPI
- Number of pages
- 19
- Identifiers
- 991013328528602368
- Copyright
- © 2020 by the authors.
- Academic Unit
- Office of Senior Deputy Vice Chancellor, Research
- Language
- English
- Resource Type
- Journal article