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Published (Version of record)CC BY V4.0, Open Access
Published (Version of record)CC BY V4.0, Open
Journal article
N-of-1 Trials in Healthcare
Healthcare (Basel), Vol.9(3), pp.1-4
15/03/2021
PMID: 33803972
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Abstract
Interest in N-of-1 trials and single-case designs is increasing worldwide, particularly
due to the movement towards personalised medicine and patient-centred healthcare.
For decades, group-based designs such as the randomised controlled trial have been
understood as the “gold standard” for testing treatments, however these designs have
provided us with little information about the individual-level improvements in health
and well-being outcomes that are of vital importance to healthcare. There is growing
recognition of the wide applicability of N-of-1 trials and single-case designs to a number
of diverse health disciplines and the value they can bring to clinical research and practice
through the focus on understanding individuals.
This Special Issue aimed to showcase novel applications of N-of-1 trials and singlecase
designs in any health-related discipline, with a specific focus on applications in new
health conditions, interventions and contexts, as well as developments in data analysis.
This Special Issue presents a collection of thirteen articles that highlight the importance of
these methods in both clinical research and practice. Together, the articles report findings
from research studies, describe protocols for future studies, and outline key discussion
points and opinions for advancing the field. The articles represent a variety of singlecase
designs, including experimental and observational designs, and demonstrate the
substantial flexibility and versatility of N-of-1 trials and single-case studies and their value
in healthcare.
Details
- Title
- N-of-1 Trials in Healthcare
- Creators
- Suzanne McDonald - Royal Brisbane and Women's HospitalJane Nikles - Royal Brisbane and Women's Hospital
- Publication Details
- Healthcare (Basel), Vol.9(3), pp.1-4
- Publisher
- Mdpi
- Number of pages
- 4
- Identifiers
- 991013054977702368
- Copyright
- © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Academic Unit
- Human Sciences; Faculty of Health
- Language
- English
- Resource Type
- Journal article