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Published (Version of record)Mycosporine-Like Amino Acids: Making the Foundation for Organic Personalised SunscreensCC BY V4.0, Open Access
Journal article
Mycosporine-like amino acids: making the foundation for organic personalised sunscreens
Marine Drugs, Vol.17(11), p.638
2019
PMID: 31726795
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Abstract
The surface of the Earth is exposed to harmful ultraviolet radiation (UVR: 280-400 nm). Prolonged skin exposure to UVR results in DNA damage through oxidative stress due to the production of reactive oxygen species (ROS). Mycosporine-like amino acids (MAAs) are UV-absorbing compounds, found in many marine and freshwater organisms that have been of interest in use for skin protection. MAAs are involved in photoprotection from damaging UVR thanks to their ability to absorb light in both the UV-A (315-400 nm) and UV-B (280-315 nm) range without producing free radicals. In addition, by scavenging ROS, MAAs play an antioxidant role and suppress singlet oxygen-induced damage. Currently, there are over 30 different MAAs found in nature and they are characterised by different antioxidative and UV-absorbing capacities. Depending on the environmental conditions and UV level, up- or downregulation of genes from the MAA biosynthetic pathway results in seasonal fluctuation of the MAA content in aquatic species. This review will provide a summary of the MAA antioxidative and UV-absorbing features, including the genes involved in the MAA biosynthesis. Specifically, regulatory mechanisms involved in MAAs pathways will be evaluated for controlled MAA synthesis, advancing the potential use of MAAs in human skin protection.
Details
- Title
- Mycosporine-like amino acids: making the foundation for organic personalised sunscreens
- Creators
- Nedeljka Rosic (Author) - Southern Cross University
- Publication Details
- Marine Drugs, Vol.17(11), p.638
- Publisher
- MDPI
- Identifiers
- 991012866500302368
- Academic Unit
- Human Sciences; Faculty of Health; School of Health and Human Sciences
- Language
- English
- Resource Type
- Journal article