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Published (Version of record)CC BY V4.0, Open Access
Published (Version of record)CC BY V4.0, Open
Journal article
Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity
Immunity, Vol.57(1), pp.171-187
09/01/2024
PMID: 38198850
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Abstract
Immune responses are tightly regulated yet highly variable between individuals. To investigate human population variation of trained immunity, we immunized healthy individuals with Bacillus Calmette-Guerin (BCG). This live -attenuated vaccine induces not only an adaptive immune response against tuberculosis but also triggers innate immune activation and memory that are indicative of trained immunity. We established personal immune profiles and chromatin accessibility maps over a 90 -day time course of BCG vaccination in 323 individuals. Our analysis uncovered genetic and epigenetic predictors of baseline immunity and immune response. BCG vaccination enhanced the innate immune response specifically in individuals with a dormant immune state at baseline, rather than providing a general boost of innate immunity. This study advances our understanding of BCG's heterologous immune -stimulatory effects and trained immunity in humans. Furthermore, it highlights the value of epigenetic cell states for connecting immune function with genotype and the environment.
Details
- Title
- Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity
- Creators
- Simone J. C. F. M. Moorlag - Radboud University Medical CenterLukas Folkman - CeMM Research Center for Molecular MedicineRob ter Horst - CeMM Research Center for Molecular MedicineThomas Krausgruber - CeMM Research Center for Molecular MedicineDaniele Barreca - CeMM Research Center for Molecular MedicineLinda C. Schuster - CeMM Research Center for Molecular MedicineVictoria Fife - CeMM Research Center for Molecular MedicineVasiliki Matzaraki - Radboud University Medical CenterWenchao Li - Centre for Individualised Infection MedicineStephan Reichl - CeMM Research Center for Molecular MedicineVera P. Mourits - Radboud University Medical CenterValerie A. C. M. Koeken - Radboud University Medical CenterCharlotte J. de Bree - Radboud University Medical CenterHelga Dijkstra - Radboud University Medical CenterHeidi Lemmers - Radboud University Medical CenterYan Li - Radboud University Medical CenterBram van Cranenbroek - Radboud University Medical CenterLeo A. B. Joosten - Radboud University NijmegenHans J. P. M. Koenen - Radboud University Medical CenterMihai G. Netea - Radboud University Medical CenterEsther van Rijssen - Radboud University Medical CenterIrma Joosten - Radboud University Medical CenterChristoph Bock - CeMM Research Center for Molecular MedicineReinout van Crevel - Radboud University Medical CenterCheng-Jia Xu - Radboud University Medical Center
- Publication Details
- Immunity, Vol.57(1), pp.171-187
- Publisher
- Elsevier
- Number of pages
- 32
- Identifiers
- 991013341145102368
- Copyright
- © 2023 The Author(s).
- Academic Unit
- Faculty of Science and Engineering
- Language
- English
- Resource Type
- Journal article