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Published (Version of record)CC BY V4.0, Open Access
Published (Version of record)CC BY V4.0, Open
Journal article
Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease
Marine Drugs, Vol.18(11), 570
2020
PMID: 33228163
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Abstract
Respiratory diseases place an immense burden on global health and there is a compelling need for the discovery of new compounds for therapeutic development. Here, we identify research priorities by critically reviewing pre-clinical and clinical studies using extracts and compounds derived from molluscs, as well as traditional molluscan medicines, used in the treatment of respiratory diseases. We reviewed 97 biomedical articles demonstrating the anti-inflammatory, antimicrobial, anticancer, and immunomodulatory properties of >320 molluscan extracts/compounds with direct relevance to respiratory disease, in addition to others with promising bioactivities yet to be tested in the respiratory context. Of pertinent interest are compounds demonstrating biofilm inhibition/disruption and antiviral activity, as well as synergism with approved antimicrobial and chemotherapeutic agents. At least 100 traditional medicines, incorporating over 300 different mollusc species, have been used to treat respiratory-related illness in cultures worldwide for thousands of years. These medicines provide useful clues for the discovery of bioactive components that likely underpin their continued use. There is particular incentive for investigations into anti-inflammatory compounds, given the extensive application of molluscan traditional medicines for symptoms of inflammation, and shells, which are the principal molluscan product used in these preparations. Overall, there is a need to target research toward specific respiratory disease-related hypotheses, purify bioactive compounds and elucidate their chemical structures, and develop an evidence base for the integration of quality-controlled traditional medicines.
Details
- Title
- Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease
- Creators
- Kate Summer - Southern Cross UniversityJessica Browne - Southern Cross UniversityLei Liu - Southern Cross UniversityKirsten Benkendorff (Corresponding Author) - Southern Cross University
- Publication Details
- Marine Drugs, Vol.18(11), 570
- Publisher
- MDPI
- Identifiers
- 991012900400002368
- Academic Unit
- School of Health and Human Sciences; Human Sciences; Faculty of Science and Engineering; Marine Ecology Research Centre; National Marine Science Centre; Science; Southern Cross Plant Science; Faculty of Health
- Language
- English
- Resource Type
- Journal article