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Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and 𝛽-Cell Dysfunction
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Journal article
Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and í µí»½-Cell Dysfunction
Oxidative medicine and cellular longevity, Vol.2015, pp.1-16
14/07/2015
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Source: InCites
Abstract
The prevalence of diabetes mellitus (DM) is increasing worldwide, a consequence of the alarming rise in obesity and metabolic syndrome (MetS). Oxidative stress and inflammation are key physiological and pathological events linking obesity, insulin resistance, and the progression of type 2 DM (T2DM). Unresolved inflammation alongside a " glucolipotoxic " environment of the pancreatic islets, in insulin resistant pathologies, enhances the infiltration of immune cells which through secretory activity cause dysfunction of insulin-secreting í µí»½-cells and ultimately cell death. Recent molecular investigations have revealed that mechanisms responsible for insulin resistance associated with T2DM are detected in conditions such as obesity and MetS, including impaired insulin receptor (IR) signalling in insulin responsive tissues, oxidative stress, and endoplasmic reticulum (ER) stress. The aim of the present review is to describe the evidence linking oxidative stress and inflammation with impairment of insulin secretion and action, which result in the progression of T2DM and other conditions associated with metabolic dysregulation.
Details
- Title
- Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and í µí»½-Cell Dysfunction
- Creators
- Kevin Noel Keane - Curtin UniversityVinicius Cruzat - Southern Cross University, Faculty of HealthRodrigo Carlessi - Curtin UniversityPaulo Ivo Homem de Bittencourt - Universidade Federal do Rio Grande do SulPhilip Newsholme - Curtin University
- Publication Details
- Oxidative medicine and cellular longevity, Vol.2015, pp.1-16
- Publisher
- Hindawi Limited
- Identifiers
- 991013071411202368
- Copyright
- Copyright © 2015 Kevin Noel Keane et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Academic Unit
- Faculty of Health
- Language
- English
- Resource Type
- Journal article