Journal article
Modulation of high fat diet-induced microbiome changes, but not behaviour, by minocycline
Brain, behavior, and immunity, Vol.82, pp.309-318
11/2019
PMID: 31493447
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Abstract
An emerging novel therapeutic agent for major depressive disorder, minocycline, has the potential to influence both gut microbiome and inflammatory status. The present study showed that chronic high fat diet feeding led to changes in both behaviour and the gut microbiome in male mice, without an overt inflammatory response. The diet-induced behavioural changes were characterised as increased immobility in the forced swim test and changes in locomotor activities in the open field test. Minocycline significantly altered the gut microbiome, rendering a community distinctly different to both untreated healthy and diet-affected states. In contrast, minocycline did not reverse high fat diet-induced changes in behaviour.
Details
- Title
- Modulation of high fat diet-induced microbiome changes, but not behaviour, by minocycline
- Creators
- Kyoko Hasebe - Deakin University (Australia, Geelong)Leni R. Rivera - Deakin University (Australia, Geelong)Craig M. Smith - Deakin University (Australia, Geelong)Theo Allnutt - Australia Bioinformatics ResourceTamsyn Crowley - Deakin University (Australia, Geelong)Tiffanie M. Nelson - Deakin University (Australia, Geelong)Olivia M. Dean - Florey Institute of Neuroscience and Mental HealthSean L. McGee - Deakin University (Australia, Geelong)Ken Waldera - Deakin University (Australia, Geelong)Laura Gray - Deakin University (Australia, Geelong)
- Publication Details
- Brain, behavior, and immunity, Vol.82, pp.309-318
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- This research was funded in part by the Rebecca L. Cooper Medical Research Foundation.
- Identifiers
- 991013328727702368
- Copyright
- © 2019 Elsevier Inc. All rights reserved.
- Academic Unit
- Office of Senior Deputy Vice Chancellor, Research
- Language
- English
- Resource Type
- Journal article