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Metaplastic carcinoma of the breast: Clinicopathological features and treatment outcomes with long-term follow up
Journal article   Open access   Peer reviewed

Metaplastic carcinoma of the breast: Clinicopathological features and treatment outcomes with long-term follow up

Aron Gortman, Noel J Aherne, Justin Westhuyzen, Julan V Amalaseelan, Patrick M Dwyer, Matthew Hoffmann, Andrew T Last and Thomas P Shakespeare
Molecular and Clinical Oncology, Vol.15(3), pp.1-6
09/2021
DOI: https://doi.org/10.3892/mco.2021.2340
PMCID: PMC8278413
PMID: 34276997
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Metaplastic carcinoma of the breastView
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Abstract

breast cancer metaplastic radiation triple negative
Metaplastic breast carcinoma is an uncommon subtype of invasive ductal carcinoma with a tendency towards poorer clinical outcomes. Following ethical approval, the current study reviewed the institutional records of ~2,500 women with breast cancer. A total of 14 cases of metaplastic breast cancer were reviewed for management and treatment outcomes. The results demonstrated that patients had median follow up of 30 months, a 5-year disease-free survival of 57.1% and 5-year overall survival of 57.1%. The majority of patients had at least T2 disease and all tumours were high grade. Additionally, most patients were triple negative and nodal metastases were uncommon. Metaplastic breast cancer is an aggressive variant of invasive breast cancer. Most patients can be treated with breast conservation and survival parameters tend to be worse than more common breast cancer subtypes.

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