Journal article
Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy
Journal of Endocrinology, Vol.222(3), pp.129-139
09/2014
Metrics
61 Record Views
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Abstract
Pigment epithelium-derived factor (PEDF) is a pluripotent glycoprotein belonging to the serpin family. PEDF can stimulate several physiological processes such as angiogenesis, cell proliferation, and survival. Oxidative stress plays an important role in the occurrence of diabetic retinopathy (DR), which is the major cause of blindness in young diabetic adults. PEDF plays a protective role in DR and there is accumulating evidence of the neuroprotective effect of PEDF. In this paper, we review the role of PEDF and the mechanisms involved in its antioxidative, anti-inflammatory, and neuroprotective properties.
Details
- Title
- Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy
- Creators
- Mina Elahy - Victoria UniversitySwati Baindur-Hudson - Victoria UniversityVinicius Cruzat - Curtin UniversityPhilip Newsholme - Curtin UniversityCrispin R. Dass - Curtin University
- Publication Details
- Journal of Endocrinology, Vol.222(3), pp.129-139
- Publisher
- BioScientifica Ltd.
- Identifiers
- 991013071410702368
- Copyright
- © 2014 Society for Endocrinology
- Academic Unit
- Faculty of Health
- Language
- English
- Resource Type
- Journal article