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Published (Version of record)CC BY V4.0, Open Access
Published (Version of record)CC BY V4.0, Open
Journal article
Measles Virus Matrix Protein Inhibits Host Cell Transcription
PloS one, Vol.11(8), e0161360
23/08/2016
PMCID: PMC4994966
PMID: 27551716
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Source: InCites
Abstract
Measles virus (MeV) is a highly contagious virus that still causes annual epidemics in developing countries despite the availability of a safe and effective vaccine. Additionally, importation from endemic countries causes frequent outbreaks in countries where it has been eliminated. The M protein of MeV plays a key role in virus assembly and cytopathogenesis; interestingly, M is localised in nucleus, cytoplasm and membranes of infected cells. We have used transient expression of M in transfected cells and in-cell transcription assays to show that only some MeV M localizes to the nucleus, in addition to cell membranes and the cytoplasm as previously described, and can inhibit cellular transcription via binding to nuclear factors. Additionally, MeV M was able to inhibit in vitro transcription in a dose-dependent manner. Importantly, a proportion of M is also localized to nucleus of MeV infected cells at early times in infection, correlating with inhibition of cellular transcription. Our data show, for the first time, that MeV M may play a role early in infection by inhibiting host cell transcription.
Details
- Title
- Measles Virus Matrix Protein Inhibits Host Cell Transcription
- Creators
- Xuelian Yu - Xinjiang Medical UniversityShadi Shahriari - University of CanberraHong-Mei Li - Monash UniversityReena Ghildyal - University of Canberra
- Publication Details
- PloS one, Vol.11(8), e0161360
- Publisher
- Public Library of Science
- Grant note
- XYL was supported by The Shanghai Municipal Health Bureau Talents Development Foundation Grant No.:GWDTR201201.
- Identifiers
- 991013035748502368
- Copyright
- © 2016 Yu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Academic Unit
- National Centre for Naturopathic Medicine
- Language
- English
- Resource Type
- Journal article