Journal article
Mango Extracts and the Mango Component Mangiferin Promote Endothelial Cell Migration
Journal of agricultural and food chemistry, Vol.58(8), pp.5181-5186
2010
PMID: 20349963
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Source: InCites
Abstract
This study tested the hypothesis that mango extracts contain bioactive molecules capable of modulating endothelial cell migration, an essential step in the formation of new blood vessels or angiogenesis. The formation of new blood vessels is an important therapeutic target for diseases such as limb ischemia, coronary infarction or stroke. We examined the effect of mango peel and flesh extracts as well as the individual polyphenolic molecules, mangiferin and quercetin, on bovine aortic cell migration using a modified Boyden chamber assay. Our results show that mangiferin, and extracts rich in mangiferin, increase endothelial cell migration. The dose−effect relationship for various extracts further suggests that this action of mangiferin is modulated by other components present in the extracts. The promigratory effect of mango extracts or mangiferin was unrelated to an effect on cell proliferation, and did not involve a change in the production of matrix metalloprotease-2 or -9 by the endothelial cells. Taken together, these results suggest that mangiferin present in mango extracts may have health promoting effects in diseases related to the impaired formation of new blood vessels.
Details
- Title
- Mango Extracts and the Mango Component Mangiferin Promote Endothelial Cell Migration
- Creators
- Noor Huda Daud - University of QueenslandCho Sanda Aung - University of QueenslandAmitha K Hewavitharana - University of QueenslandAshley S Wilkinson - University of QueenslandJean-Thomas Pierson - University of QueenslandSarah J Roberts-Thomson - University of QueenslandP. Nicholas Shaw - University of QueenslandGregory R Monteith - University of QueenslandMichael J Gidley - University of QueenslandMarie-Odile Parat (Corresponding Author) - University of Queensland
- Publication Details
- Journal of agricultural and food chemistry, Vol.58(8), pp.5181-5186
- Publisher
- American Chemical Society
- Identifiers
- 991012894199202368
- Academic Unit
- Faculty of Science and Engineering; Southern Cross Plant Science; Science
- Language
- English
- Resource Type
- Journal article