Journal article
Low-dose ketamine provides poor analgesia for pain in redback spider envenoming
British journal of clinical pharmacology, Vol.85(10), pp.2423-2427
10/2019
PMID: 31269538
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Source: InCites
Abstract
Redback spider envenoming causes severe pain lasting several days. A recent clinical trial found that antivenom is not effective. We investigated ketamine for pain in redback spider envenoming. Ten adult patients with severe pain from redback spider envenoming were administered 15 mg intravenous ketamine after standard analgesia, then up to 4 oral doses of ketamine 25- 50 mg. Three patients had a clinically significant improvement in pain compared to baseline after intravenous ketamine. Five patients had a minimal decrease in pain and 2 had no improvement. Eight patients received oral ketamine: 4 doses in 5 and 2 doses in 3. At 24 h, 3/6 patients assessed had clinically significant improvement in pain and 4/5 patients assessed at 48 h, had clinically significant improvement in pain. Six patients reported side effects, including dissociation (4) and hallucinations (2). Five patients required rescue opioids and 2 were readmitted to hospital. We found that ketamine provided no additional pain relief in redback spider envenoming, compared to standard analgesia, and resulted in unacceptable adverse effects.
Details
- Title
- Low-dose ketamine provides poor analgesia for pain in redback spider envenoming
- Creators
- Nicole M Ryan (Author) - University of Newcastle AustraliaRosemary James (Author) - Calvary Mater Newcastle HospitalMichael A. Downes (Author) - University of Newcastle AustraliaGeoffrey K. Isbister (Corresponding Author) - University of Newcastle Australia
- Publication Details
- British journal of clinical pharmacology, Vol.85(10), pp.2423-2427
- Publisher
- Wiley
- Grants
- NHMRC CRE, 1110343, National Health and Medical Research Council (Australia, Canberra) - NHMRC
- Grant note
- National Health and Medical Research Council. Grant Numbers: 1061041, 1110343: NHMRC Centre for Research Excellence. Grant Number: 1110343 NHMRC Senior Research Fellowship. Grant Number: 1061041
- Identifiers
- 991013151813602368
- Copyright
- © 2019 The British Pharmacological Society
- Academic Unit
- Faculty of Health
- Language
- English
- Resource Type
- Journal article