Journal article
Longer term outcomes following serogroup B invasive meningococcal disease
Journal of paediatrics and child health, Vol.57(6), pp.894-902
06/2021
PMID: 33460220
Metrics
11 Record Views
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Abstract
Aim
To characterise the physical, psychological, and quality of life burden associated with serogroup B invasive meningococcal disease (IMD) in children.
Methods
Children aged up to 14 years at the time of serogroup B IMD, who were admitted to intensive care units of two tertiary paediatric hospitals in New South Wales, Australia between January 2009 and December 2013 were recruited. Children underwent clinical and neuropsychological assessments up to 6 years post-disease.
Results
Eleven children were assessed, with a median age of 16 months (range 4–46 months) at time of disease. The median follow-up time was 50 months (range 10–67 months). Seven (63.6%) cases had one or more long-term sequelae involving permanent and evolving physical disability. Three cases had ongoing medical conditions including two with seizures and one with ataxia and hypermetropia. Five required ongoing medical and allied health care. Other complications identified included anxiety, speech delay, low average full-scale IQ score (median 85, interquartile range 89–103) and borderline memory impairment.
Conclusions
Serogroup B IMD is associated with significant long-term morbidity and burden on the child and family with substantial economic implications. The impact of this on the total cost of IMD needs to be further quantified, and better considered in vaccine cost-effectiveness analyses.
Details
- Title
- Longer term outcomes following serogroup B invasive meningococcal disease
- Creators
- Lucy Deng - National Centre for Immunisation Research & SurveillanceBelinda Barton - University of SydneyJennifer Lorenzo - Children's Hospital at WestmeadHarunor Rashid - National Centre for Immunisation Research & SurveillanceFereshteh Dastouri - University of SydneyRobert Booy - National Centre for Immunisation Research & Surveillance
- Publication Details
- Journal of paediatrics and child health, Vol.57(6), pp.894-902
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- Confederation of Meningitis Organisations
- Identifiers
- 991013092668702368
- Copyright
- © 2021 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).
- Academic Unit
- Faculty of Health
- Language
- English
- Resource Type
- Journal article