Background: Despite the health benefits of breastfeeding, initiation and duration rates continue to fall short of international guidelines. Many factors influence a woman's decision to wean; the main reason cited for weaning is associated with lactation complications, such as mastitis.
Objectives: To assess the effects of preventive strategies for mastitis and the subsequent effect on breastfeeding duration.
Search strategy: We searched the Cochrane Pregnancy and Childbirth Group¿s Trials Register (November 2009), CENTRAL (The Cochrane Library 2009, Issue 4), MEDLINE (1950 to November 2009), EMBASE (1974 to November 2009), CINAHL (1981 to November 2009), MIDIRS (1971 to November 2009), IPA (1970 to November 2009), AMED (1985 to November 2009) and LILACS (1982 to November 2009).
Selection criteria: We included randomised controlled trials of interventions for preventing mastitis in postpartum breastfeeding women.
Data collection and analysis: We independently identified relevant studies and assessed the trial quality. We contacted trial authors for missing data and information as appropriate.
Main results: We included five trials (involving 960 women). In three trials of 471 women, we found no significant differences in the incidence of mastitis between use of antibiotics and no antibiotics (risk ratio (RR) 0.43; 95% confidence interval (CI) 0.11 to 1.61; or in one trial of 99 women comparing two doses (RR 0.38; 95% CI 0.02 to 9.18). We found no significant differences for mastitis in three trials of specialist breastfeeding education with usual care (one trial); anti-secretory factor cereal (one trial); and mupirocin, fusidic acid ointment or breastfeeding advice (one trial). Generally we found no differences in any of the trials for breastfeeding initiation or duration; or symptoms of mastitis.