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Intergenerational epigenetic inheritance in reef-building corals
Journal article   Open access   Peer reviewed

Intergenerational epigenetic inheritance in reef-building corals

Yi Jin Liew, Emily J Howells, Xin Wang, Craig Michell, John A Burt, Youssef Idaghdour and Manuel Aranda
Nature climate change, Vol.10, pp.254-259
10/02/2020
DOI: https://doi.org/10.1038/s41558-019-0687-2
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Intergenerational epigenetic inheritance in reef-building coralsView
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Preprint: Intergenerational epigenetic inheritance in reef-building coralsView
Preprint (Author's original)bioRxiv preprint doi: https://doi.org/10.1101/269076; this version posted February 21, 2018CC BY V4.0,  Open
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Extended Data Fig. 1 Methylation in P. daedalea is more commonly found in genic regions, and concentrated closer to the 5’ and 3’ endsView
Supplementary Material (supplemental)Free to Read,  Open
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Extended Data Fig. 2 Per-origin principal components analysis of DNA methylation patterns in P. daedaleaView
Supplementary Material (supplemental)Free to Read,  Open
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Extended Data Fig. 3 Methylation trends against FST are origin-agnosticView
Supplementary Material (supplemental)Free to Read,  Open

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Abstract

cnidarian coral DNA methylation Epigenetics intergenerational inheritance
The perception that the inheritance of phenotypic traits operates solely through genetic means is slowly being eroded: epigenetic mechanisms have been shown to induce heritable changes in gene activity in plants1,2 and metazoans1,3. Inheritance of DNA methylation patterns provides a potential pathway for environmentally induced phenotypes to contribute to evolution of species and populations1,2,3,4,5. However, in basal metazoans, it is unknown whether inheritance of CpG methylation patterns occurs across the genome (as in plants) or as rare exceptions (as in mammals)4. Here, we show that DNA methylation patterns in a reef-building coral are determined by genotype and developmental stage, as well as by parental environment. Transmission of CpG methylation from adults to their sperm and larvae demonstrates genome-wide inheritance. Variation in the hypermethylation of genes in adults and their sperm from distinct environments suggests intergenerational acclimatization to local temperature and salinity. Furthermore, genotype-independent adjustments of methylation levels in stress-related genes were strongly correlated with offspring survival rates under heat stress. These findings support a role of DNA methylation in the intergenerational inheritance of traits in corals, which could extend to enhancing their capacity to adapt to climate change. We thank D. Abrego, G. Vaughan and D. McParland for assistance with fieldwork, coral spawning and the collection of environmental data. We thank the NYUAD Core Research Vessel and The Palms Dive Center for fieldwork support. We thank the Environment Agency Abu Dhabi and Fujairah Municipality for research permits and the KAUST Sequencing Core Facility for the sequencing of the libraries. The research reported in this publication was supported by the KAUST OSR under grant no. URF/1/3447-01-01, as well as baseline support to M.A.; and by NYUAD research grant no. AD105 to Y.I.

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