Intellectual and academic outcomes after pediatric liver transplantation: Relationship with transplant-related factors

Soheil Afshar; Melanie Porter; Belinda Barton; Michael Stormon

doi:10.1111/ajt.14924

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Intellectual and academic outcomes after pediatric liver transplantation: Relationship with transplant-related factors

Journal article

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Intellectual and academic outcomes after pediatric liver transplantation: Relationship with transplant-related factors

Soheil Afshar, Melanie Porter, Belinda Barton and Michael Stormon

American journal of transplantation, Vol.18(9), pp.2229-2237

09/2018

DOI: https://doi.org/10.1111/ajt.14924

PMID: 29745028

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Abstract

Life Sciences & Biomedicine

Science & Technology

Surgery

Transplantation

health services and outcomes research

liver transplantation/hepatology

pediatrics

quality of life (QOL)

waitlist management

As survival rates for pediatric liver transplant continue to increase, research attention is turning toward long-term functional consequences, with particular interest in whether medical and transplant-related factors are implicated in neurocognitive outcomes. The relative importance of different factors is unclear, due to a lack of methodological uniformity, inclusion of differing primary diagnoses, varying transplant policies, and organ availability in different jurisdictions. This cross-sectional, single-site study sought to address various methodological limitations in the literature and the paucity of studies conducted outside of North America and Western Europe by examining the intellectual and academic outcomes of Australian pediatric liver transplant recipients (N = 40). Participants displayed significantly poorer intellectual and mathematical abilities compared with the normative population. Greater time on the transplant waitlist was a significant predictor of poorer verbal intelligence, working memory, mathematical abilities, and reading but only when considering the subgroup of children with biliary atresia. These findings support reducing the time children wait for a transplant as a priority.

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Title: Intellectual and academic outcomes after pediatric liver transplantation: Relationship with transplant-related factors
Creators: Soheil Afshar - Macquarie University
Melanie Porter - Macquarie University
Belinda Barton - Children's Hospital at Westmead
Michael Stormon - Children's Hospital at Westmead
Publication Details: American journal of transplantation, Vol.18(9), pp.2229-2237
Publisher: Wiley
Number of pages: 9
Grant note: This research was supported by an Australian Postgraduate Award student funding and student support scheme funds from Macquarie University and the LTU at The Children’s Hospital at Westmead.
Identifiers: 991013092667202368
Copyright: © 2018 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier Inc. Open access: Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)
Academic Unit: Faculty of Health
Language: English
Resource Type: Journal article

Intellectual and academic outcomes after pediatric liver transplantation: Relationship with transplant-related factors

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