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Published (Version of record)CC BY V4.0, Open Access
Published (Version of record)CC BY V4.0, Open
Journal article
Insights into the multifaceted role of interleukin-37 on human immune cell regulation
Clinical immunology, Vol.268, pp.1-13
11/2024
PMID: 39307482
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Abstract
Autoinflammatory diseases, while having a variety of underlying causes, are mediated by dysfunctional innate immune responses. Therefore, standard treatments target innate cytokines or block their receptors. Despite excellent responses in some patients, first-line treatments fail in others, for reasons which remain to be understood. We studied the effects of IL-37, an anti-inflammatory cytokine, on immune cells using multi-omics profiling of 325 healthy adults. Our findings show that IL-37 is associated with inflammation control and generally reduced immune cell activity. Further, genetic variants in IL37 are associated with impaired trained immunity, a memory phenotype of innate immune cells contributing to autoinflammation. To underpin the medical potential of IL-37, an explorative cohort of seven autoinflammatory disorders was built. In vitro stimulation experiments argue for recombinant IL-37 as a potential therapy in IL-6-, and IL-22-driven conditions. Concluding, IL-37 is highlighted as a cytokine with broad anti-inflammatory functions, implicating its potential as therapeutic intervention.
Details
- Title
- Insights into the multifaceted role of interleukin-37 on human immune cell regulation
- Creators
- Lisa U. Teufel - Radboud University Medical CenterVasiliki Matzaraki - Radboud University Medical CenterLukas Folkman - CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (Austria)Rob ter Horst - CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (Austria)Simone J. C. F. M. Moorlag - Radboud University Medical CenterCatharina M. Mulders-Manders - Radboud University Medical CenterMihai G. Netea - Radboud University Medical CenterThomas Krausgruber - CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (Austria)Leo A. B. Joosten - Radboud University Medical CenterRob J.W. Arts - Radboud University Medical Center
- Publication Details
- Clinical immunology, Vol.268, pp.1-13
- Publisher
- Elsevier Inc
- Grant note
- VENI: 09150161810007 Advanced grant of the European Research Council (ERC): 833247 Spinoza grant of the Dutch Research Council: NWO SPI 94-212 Competitiveness Operation Program grant of the Romanian Ministry of European Funds: P_37_762, MySMIS 103587 Marie Sklodowska-Curie Actions Individual Fellowship: 842480 EMBO Postdoctoral Fellowship: ALTF 702-2020 Marie Curie Actions (MSCA): 842480
R.J.W.A. is supported by the VENI grant (09150161810007) . M.G.N. is supported by an Advanced grant of the European Research Council (ERC, #833247) and a Spinoza grant of the Dutch Research Council (NWO SPI 94-212) . L.A.B.J. is supported by a Competitiveness Operation Program grant of the Romanian Ministry of European Funds (HINT, ID P_37_762; MySMIS 103587) . L.F. was supported by a Marie Sklodowska-Curie Actions Individual Fellowship (grant agreement no. 842480) . R.t.H. was supported by an EMBO Postdoctoral Fellowship (grant agreement no. ALTF 702-2020) .
- Identifiers
- 991013345939702368
- Copyright
- © 2024 The Authors.
- Academic Unit
- Faculty of Science and Engineering
- Language
- English
- Resource Type
- Journal article