Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease

Giuseppe Verdile; Kevin Noel Keane; Vinicius Cruzat; Sandra Medic; Miheer Sabale; Joanne Elizabeth Rowles; Nadeeja Wijesekara; Ralph N. Martins; Paul E. Fraser; Philip Newsholme

doi:10.1155/2015/105828

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Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease

Journal article

Open access

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Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease

Giuseppe Verdile, Kevin Noel Keane, Vinicius Cruzat, Sandra Medic, Miheer Sabale, Joanne Elizabeth Rowles, Nadeeja Wijesekara, Ralph N. Martins, Paul E. Fraser and Philip Newsholme

Mediators of inflammation, Vol.2015, pp.1-18

26/11/2015

DOI: https://doi.org/10.1155/2015/105828

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Abstract

Type 2 diabetes (T2DM), Alzheimer’s disease (AD), and insulin resistance are age-related conditions and increased prevalence is of public concern. Recent research has provided evidence that insulin resistance and impaired insulin signalling may be a contributory factor to the progression of diabetes, dementia, and other neurological disorders. Alzheimer’s disease (AD) is the most common subtype of dementia. Reduced release (for T2DM) and decreased action of insulin are central to the development and progression of both T2DM and AD. A literature search was conducted to identify molecular commonalities between obesity, diabetes, and AD. Insulin resistance affects many tissues and organs, either through impaired insulin signalling or through aberrant changes in both glucose and lipid (cholesterol and triacylglycerol) metabolism and concentrations in the blood. Although epidemiological and biological evidence has highlighted an increased incidence of cognitive decline and AD in patients with T2DM, the common molecular basis of cell and tissue dysfunction is rapidly gaining recognition. As a cause or consequence, the chronic inflammatory response and oxidative stress associated with T2DM, amyloid-β (Aβ) protein accumulation, and mitochondrial dysfunction link T2DM and AD.

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Title: Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease
Creators: Giuseppe Verdile - Edith Cowan University
Kevin Noel Keane - Curtin University
Vinicius Cruzat - Curtin University
Sandra Medic - Curtin University
Miheer Sabale - Curtin University
Joanne Elizabeth Rowles - Curtin University
Nadeeja Wijesekara - University of Toronto
Ralph N. Martins - Edith Cowan University
Paul E. Fraser - University of Toronto
Philip Newsholme - Curtin University
Publication Details: Mediators of inflammation, Vol.2015, pp.1-18
Publisher: Hindawi Limited
Identifiers: 991013071411302368
Copyright: Copyright © 2015 Giuseppe Verdile et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Academic Unit: Faculty of Health
Language: English
Resource Type: Journal article

Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease

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UN Sustainable Development Goals (SDGs)

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